Human correlates of provocative questions in pancreatic pathology

Oliver G. McDonald, Anirban Maitra, Ralph H. Hruban

Research output: Contribution to journalReview article

Abstract

Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that "genetic signals" may be more accurate than today's multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on "the evidence derived from man."

Original languageEnglish (US)
Pages (from-to)351-362
Number of pages12
JournalAdvances in anatomic pathology
Volume19
Issue number6
DOIs
StatePublished - Nov 1 2012

Keywords

  • Epithelial-mesenchymal transition
  • Metastasis
  • Pancreas
  • Pancreatic cancer
  • Stroma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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