TY - JOUR
T1 - Human copper homeostasis
T2 - a network of interconnected pathways
AU - Lutsenko, Svetlana
N1 - Funding Information:
This work has been funded by the NIH grants R01 DK071865 and P01 GM067166 to SL.
PY - 2010/4
Y1 - 2010/4
N2 - Copper plays an essential role in normal human physiology. Copper misbalance affects heart development, CNS and liver function, influences lipid metabolism, inflammation, and resistance to chemotherapeutic drugs. Recent studies yielded new information on the structure, function, and regulation of human copper transporters, uncovered unanticipated functions for copper chaperones, and established connections between copper homeostasis and other metabolic pathways. It has become apparent that the copper trafficking machinery is regulated at several levels and that the cross-talk between cell compartments contributes to the intracellular copper balance. The human copper regulon is emerging.
AB - Copper plays an essential role in normal human physiology. Copper misbalance affects heart development, CNS and liver function, influences lipid metabolism, inflammation, and resistance to chemotherapeutic drugs. Recent studies yielded new information on the structure, function, and regulation of human copper transporters, uncovered unanticipated functions for copper chaperones, and established connections between copper homeostasis and other metabolic pathways. It has become apparent that the copper trafficking machinery is regulated at several levels and that the cross-talk between cell compartments contributes to the intracellular copper balance. The human copper regulon is emerging.
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U2 - 10.1016/j.cbpa.2010.01.003
DO - 10.1016/j.cbpa.2010.01.003
M3 - Review article
C2 - 20117961
AN - SCOPUS:77949917893
SN - 1367-5931
VL - 14
SP - 211
EP - 217
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 2
ER -