Human cartilage repair with a photoreactive adhesive-hydrogel composite

Blanka Sharma, Sara Fermanian, Matthew Gibson, Shimon Unterman, Daniel Herzka, Brett Cascio, Jeannine Coburn, Alexander Y. Hui, Norman Marcus, Garry E. Gold, Jennifer Hartt Elisseeff

Research output: Contribution to journalArticle

Abstract

Surgical options for cartilage resurfacing may be significantly improved by advances and application of biomaterials that direct tissue repair. A poly(ethylene glycol) diacrylate (PEGDA) hydrogel was designed to support cartilage matrix production, with easy surgical application. A model in vitro system demonstrated deposition of cartilage-specific extracellular matrix in the hydrogel biomaterial and stimulation of adjacent cartilage tissue development by mesenchymal stem cells. For translation to the joint environment, a chondroitin sulfate adhesive was applied to covalently bond and adhere the hydrogel to cartilage and bone tissue in articular defects. After preclinical testing in a caprine model, a pilot clinical study was initiated where the biomaterials system was combined with standard microfracture surgery in 15 patients with focal cartilage defects on the medial femoral condyle. Control patients were treated with microfracture alone. Magnetic resonance imaging showed that treated patients achieved significantly higher levels of tissue fill compared to controls. Magnetic resonance spin-spin relaxation times (T 2) showed decreasing water content and increased tissue organization over time. Treated patients had less pain compared with controls, whereas knee function [International Knee Documentation Committee (IKDC)] scores increased to similar levels between the groups over the 6 months evaluated. No major adverse events were observed over the study period. With further clinical testing, this practical biomaterials strategy has the potential to improve the treatment of articular cartilage defects.

Original languageEnglish (US)
Article number167ra6
JournalScience Translational Medicine
Volume5
Issue number167
DOIs
StatePublished - Jan 9 2013

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Hydrogel
Adhesives
Cartilage
Biocompatible Materials
Stress Fractures
Knee
Joints
Bone and Bones
Chondroitin Sulfates
Articular Cartilage
Thigh
Mesenchymal Stromal Cells
Documentation
Extracellular Matrix
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Pain
Water

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Human cartilage repair with a photoreactive adhesive-hydrogel composite. / Sharma, Blanka; Fermanian, Sara; Gibson, Matthew; Unterman, Shimon; Herzka, Daniel; Cascio, Brett; Coburn, Jeannine; Hui, Alexander Y.; Marcus, Norman; Gold, Garry E.; Elisseeff, Jennifer Hartt.

In: Science Translational Medicine, Vol. 5, No. 167, 167ra6, 09.01.2013.

Research output: Contribution to journalArticle

Sharma, B, Fermanian, S, Gibson, M, Unterman, S, Herzka, D, Cascio, B, Coburn, J, Hui, AY, Marcus, N, Gold, GE & Elisseeff, JH 2013, 'Human cartilage repair with a photoreactive adhesive-hydrogel composite', Science Translational Medicine, vol. 5, no. 167, 167ra6. https://doi.org/10.1126/scitranslmed.3004838
Sharma, Blanka ; Fermanian, Sara ; Gibson, Matthew ; Unterman, Shimon ; Herzka, Daniel ; Cascio, Brett ; Coburn, Jeannine ; Hui, Alexander Y. ; Marcus, Norman ; Gold, Garry E. ; Elisseeff, Jennifer Hartt. / Human cartilage repair with a photoreactive adhesive-hydrogel composite. In: Science Translational Medicine. 2013 ; Vol. 5, No. 167.
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