Human caliciviruses as a cause of severe gastroenteritis in Peruvian children

Umesh D. Parashar, Jin Fen Li, Rosa Cama, Mark DeZalia, Stephan S. Monroe, David N. Taylor, Dante Figueroa, Robert H. Gilman, Roger I. Glass

Research output: Contribution to journalArticlepeer-review

Abstract

To define the role of human caliciviruses (HuCVs) in severe childhood gastroenteritis, fecal and paired serum samples from 233 Peruvian children hospitalized with gastroenteritis (case patients) and fecal samples from 248 control subjects were evaluated. Overall, 128 case patients (55%) demonstrated HuCV infection by either fecal (n = 81 [35%]) or serological (n = 96 [41%]) testing. HuCVs were more prevalent in fecal samples from case patients than those from control subjects (35% vs. 13%; P < .001). HuCV infection was more prevalent among case patients without another pathogen than in those who had a coinfecting pathogen (77% [40/52] vs. 49% [88/181]; P < .001). HuCVs appear to be an important cause of gastroenteritis in Peruvian children.

Original languageEnglish (US)
Pages (from-to)1088-1092
Number of pages5
JournalJournal of Infectious Diseases
Volume190
Issue number6
DOIs
StatePublished - Sep 15 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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