Human breast carcinoma cell levels of MDR-1 (P-glycoprotein) transcripts correlate in vivo inversely and reciprocally with tumor progesterone receptor content.

B. M. Kacinski, L. D. Yee, D. Carter, D. Li, M. T. Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

Sixteen human breast carcinomas were subjected to molecular biological and biochemical analyses to determine tumor cell MDR-1 (P-glycoprotein) levels and progesterone receptor content. The results of these analyses disclosed a strong reciprocal and inverse correlation between levels of tumor cell-specific MDR-1 complementary hybrids and progesterone receptor content. These results suggest that the mechanisms which control expression of the P-glycoprotein gene and the progesterone receptor are interrelated and antagonistic, a result with obvious molecular biological, physiological, and clinical implications.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCancer Communications
Volume1
Issue number1
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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