Human brain imaging in HIV and neuroAIDS

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The introduction of combination antiretroviral therapy (cART) has significantly decreased the severity of HIV-associated neurocognitive disorder (HAND) and increased the life expectancy of the human immunodeficiency virus (HIV) positive population. Nevertheless, patients still show persistent neurocognitive disorders due to associated structural and functional brain changes. The purpose of this chapter is to highlight the significance of brain neuroimaging techniques and biomarkers in understanding the pathophysiology related to HIV infection and HAND. These imaging modalities include volumetric (MRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), single-photon emission computed tomography (SPECT), diffusion tensor imaging (DTI), arterial spin labeling (ASL), and perfusion MRI. The authors predict that with neuroimaging advances at the molecular level, it will soon be the noninvasive gold standard in brain pathology diagnosis.

Original languageEnglish (US)
Title of host publicationGlobal Virology II - HIV and NeuroAIDS
PublisherSpringer New York
Pages93-110
Number of pages18
ISBN (Electronic)9781493972906
ISBN (Print)9781493972883
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biomarkers
  • Brain
  • DTI
  • HAND
  • HIV
  • Imaging
  • MRI
  • MRS
  • NeuroAIDS
  • PET

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

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  • Cite this

    Mohamed, M. (2017). Human brain imaging in HIV and neuroAIDS. In Global Virology II - HIV and NeuroAIDS (pp. 93-110). Springer New York. https://doi.org/10.1007/978-1-4939-7290-6_6