Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function

Xiaoyu Zhang, Haidong Dong, Wei Lin, Stephen Voss, Lucinda Hinkley, Melissa Westergren, Guoliang Tian, Daniel Berry, David Lewellen, Richard G. Vile, Lieping Chen, Donna L. Farber, Scott E. Strome

Research output: Contribution to journalArticle

Abstract

The role of human bone marrow (BM) CD8+ T cells in the immune response to viral Ags is poorly defined. We report here the identification and characterization of a functionally enhanced effector memory CD8+ T cell population (TEM) in the BM of patients undergoing total joint replacement for osteoarthritis. These BM-derived TEM differ strikingly from correlate cells in peripheral blood (PB), expressing elevated levels of CD27, HLA-DR, CD38, CD69, and unique patterns of chemokine receptors. Interestingly, while BM TEM have low levels of resting perform and granzyme B, these molecules evidence profound up-regulation in response to TCR stimulation resulting in enhanced cytotoxic potential. Moreover, compared with the TEM subset in PB, BM CD8+ TEM cells demonstrate a more vigorous recall response to pooled viral Ags. Our results reveal that human BM serves as a repository for viral Ag-spccific TEM with great therapeutic potential in vaccine development.

Original languageEnglish (US)
Pages (from-to)6730-6737
Number of pages8
JournalJournal of Immunology
Volume177
Issue number10
StatePublished - Nov 15 2006

ASJC Scopus subject areas

  • Immunology

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    Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L., & Strome, S. E. (2006). Human bone marrow: A reservoir for "enhanced effector memory" CD8+ T cells with potent recall function. Journal of Immunology, 177(10), 6730-6737.