Human biodistribution and radiation dosimetry of 82Rb

Srinivasan Senthamizhchelvan, Paco E. Bravo, Caroline Esaias, Martin A. Lodge, Jennifer Merrill, Robert F. Hobbs, George Sgouros, Frank M. Bengel

Research output: Contribution to journalArticlepeer-review

Abstract

Prior estimates of radiation-absorbed doses from 82Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated 82Rb dosimetry using human in vivo biokinetic measurements. Methods: Ten healthy volunteers underwent dynamic PET/CT (6 contiguous table positions, each with separate 82Rb infusion). Source organ volumes of interest were delineated on the CT images and transferred to the PET images to obtain time-integrated activity coefficients. Radiation doses were estimated using OLINDA/EXM 1.0. Results: The highest mean absorbed organ doses (μGy/MBq) were observed for the kidneys (5.81), heart wall (3.86), and lungs (2.96). Mean effective doses were 1.11 ± 0.22 and 1.26 ± 0.20 mSv/MBq using the tissue-weighting factors of the International Commission on Radiological Protection (ICRP), publications 60 and 103, respectively. Conclusion: Our current 82Rb dosimetry suggests reasonably low radiation exposure. On the basis of this study, a clinical 82Rb injection of 2 x 1,480 MBq (80 mCi) would result in a mean effective dose of 3.7 mSv using the weighting factors of the ICRP 103 - only slightly above the average annual natural background exposure in the United States (3.1 mSv).

Original languageEnglish (US)
Pages (from-to)1592-1599
Number of pages8
JournalJournal of Nuclear Medicine
Volume51
Issue number10
DOIs
StatePublished - Oct 1 2010

Keywords

  • Dosimetry
  • Imaging
  • Myocardium
  • Positron emission tomography
  • Rb

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Human biodistribution and radiation dosimetry of <sup>82</sup>Rb'. Together they form a unique fingerprint.

Cite this