Human Autoreactive CD4+ T Cell Clones Use Perforin- or Fas/Fas Ligand-Mediated Pathways for Target Cell Lysis

Marco Vergelli, Bernhard Hemmer, Paolo A. Muraro, Laura Tranquill, William E. Biddison, Apurva Sarin, Henry F. McFarland, Roland Martin

Research output: Contribution to journalArticle

Abstract

It is well established that target cell lysis by MHC class I-restricted CD8+ T cells is an important defense mechanism during infections with intracellular pathogens or against tumor targets. On the other hand, little is known about the physiologic role and the mechanisms of cytotoxicity of CD4+ MHC class II-restricted T cells. We have recently demonstrated that human autoreactive CD4+ T cells specific for one candidate autoantigen of multiple sclerosis, myelin basic protein, can mediate cytotoxicity. In the present report, we analyze the cytolytic mechanisms employed by these cells. We show that individual T cell clones, regardless of their cytokine phenotype, can be noncytotoxic or lyse target cells via either perforin- or Fas/Fas ligand-mediated cytotoxicity.

Original languageEnglish (US)
Pages (from-to)2756-2761
Number of pages6
JournalJournal of Immunology
Volume158
Issue number6
StatePublished - Mar 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Vergelli, M., Hemmer, B., Muraro, P. A., Tranquill, L., Biddison, W. E., Sarin, A., McFarland, H. F., & Martin, R. (1997). Human Autoreactive CD4+ T Cell Clones Use Perforin- or Fas/Fas Ligand-Mediated Pathways for Target Cell Lysis. Journal of Immunology, 158(6), 2756-2761.