Human autoimmune neuropathies

T. W. Ho, G. M. McKhann, J. W. Griffin

Research output: Contribution to journalReview articlepeer-review


Peripheral nerve diseases are among the most prevalent disorders of the nervous system. Because of the accessibility of the peripheral nervous system (PNS) to direct physiological and pathological study, neuropathies have traditionally played a unique role in developing our understanding of basic mechanism of nervous system injury and repair. At present they are providing new insight into the mechanisms of immune injury to the nervous system. A rapidly growing catalogue of PNS disorders are now suspected to be immune- mediated, and in the best understood of these disorders, the molecular and cellular targets of immune attack are known, and the pathophysiology follows directly from the specific immune injury. This review summarizes the immunologically relevant features of the PNS, then considers selected immune- mediated neuropathies, focusing on pathogenetic mechanisms. Finally, the PNS is providing a testing ground for new immunotherapies and approaches to protection and regeneration, including the use of trophic factors. The current status of treatment and implications for future approaches is reviewed.

Original languageEnglish (US)
Pages (from-to)187-226
Number of pages40
JournalAnnual review of neuroscience
StatePublished - Apr 15 1998


  • Autoimmunity
  • Demyelination
  • Guillain-Barre syndrome
  • Peripheral nerves

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Human autoimmune neuropathies'. Together they form a unique fingerprint.

Cite this