Human atrial natriuretic peptide infusion for a neonate with congestive heart failure after total correction of total anomalous pulmonary venous connection

M. Hamawaki, T. Tomino, H. Sato, M. Imura, T. Suzuki, Narutoshi Hibino

Research output: Contribution to journalArticlepeer-review

Abstract

A successful case of human atrial natriuretic peptide (HANP) infusion therapy for a neonate who developed congestive heart failure (CHF) after total repair of total anomalous pulmonary venous connection was performed on the first day of life. Following 14h of HANP infusion at incremental doses of 0.125-0.25μg · kg-1 · min-1, urine output and hemodynamics dramatically improved. Urine output increased from 1.1 to 10.6 ml/h (p<0.0001) and good urinary output (13.0 ml/h) was maintained even after discontinuation of the infusion. During the infusion, the heart rate decreased from 166 to 152 beats/min (p<0.0001), and the systemic systolic blood pressure increased from 82 to 103 mmHg (p<0.0001). Central venous pressure was not significantly affected by HANP infusion. This is the first successful case of HANP infusion therapy as the first treatment of post-operative pulmonary hypertension in this age group. This therapy can be used safely and may be useful in neonates with CHF resulting from other causes, but more investigation is needed.

Original languageEnglish (US)
Pages (from-to)708-710
Number of pages3
JournalJapanese Circulation Journal
Volume64
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Congestive heart failure
  • Human atrial natriuretic peptide
  • Neonate
  • Pulmonary hypertension
  • Total anomalous pulmonary venous connection

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Human atrial natriuretic peptide infusion for a neonate with congestive heart failure after total correction of total anomalous pulmonary venous connection'. Together they form a unique fingerprint.

Cite this