Human Apolipoprotein D Gene: Gene Sequence, Chromosome Localization, and Homology to the α2u-Globulin Superfamily

Dennis T. Drayna, John W. Mclean, Karen L. Wion, Jeffrey M. Trent, Harry A. Drabkin, Richard M. Lawn

Research output: Contribution to journalArticlepeer-review

Abstract

The exons and bordering intron nucleotides of the human apolipoprotein D (apo D) gene have been sequenced. The protein-coding portion of the gene is divided into five exons which span ∼12,000 bp. At least one intron interrupts the 5′ untranslated region. The gene has been localized to the pl4.2→qter region of human chromosome 3. Apo D shares homology with the α2u-globulin superfamily of genes, including ∼25% amino acid homology with human retinol-binding protein (RBP). Similarity of intron locations in both apo D and RBP suggests that these two genes derived from a common ancestor.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalDNA
Volume6
Issue number3
DOIs
StatePublished - Jun 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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