Human and mouse hypoxanthine-guanine phosphoribosyltransferase: Dimers and tetramers

Gerald G. Johnson, Lorraine R. Eisenberg, Barbara R. Migeon

Research output: Contribution to journalArticlepeer-review

Abstract

Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.

Original languageEnglish (US)
Pages (from-to)174-176
Number of pages3
JournalScience
Volume203
Issue number4376
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • General

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