Human Alu element retrotransposition induced by genotoxic stress

Christy R. Hagan, Rebecca F. Sheffield, Charles M. Rudin

Research output: Contribution to journalArticlepeer-review


Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

Original languageEnglish (US)
Pages (from-to)219-220
Number of pages2
JournalNature Genetics
Issue number3
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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