Human Alu element retrotransposition induced by genotoxic stress

Christy R. Hagan, Rebecca F. Sheffield, Charles M. Rudin

Research output: Contribution to journalArticle

Abstract

Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

Original languageEnglish (US)
Pages (from-to)219-220
Number of pages2
JournalNature Genetics
Volume35
Issue number3
DOIs
StatePublished - Nov 2003
Externally publishedYes

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Alu Elements
DNA Damage
Topoisomerase II Inhibitors
Human Genome
Etoposide
Primates

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Hagan, C. R., Sheffield, R. F., & Rudin, C. M. (2003). Human Alu element retrotransposition induced by genotoxic stress. Nature Genetics, 35(3), 219-220. https://doi.org/10.1038/ng1259

Human Alu element retrotransposition induced by genotoxic stress. / Hagan, Christy R.; Sheffield, Rebecca F.; Rudin, Charles M.

In: Nature Genetics, Vol. 35, No. 3, 11.2003, p. 219-220.

Research output: Contribution to journalArticle

Hagan, CR, Sheffield, RF & Rudin, CM 2003, 'Human Alu element retrotransposition induced by genotoxic stress', Nature Genetics, vol. 35, no. 3, pp. 219-220. https://doi.org/10.1038/ng1259
Hagan, Christy R. ; Sheffield, Rebecca F. ; Rudin, Charles M. / Human Alu element retrotransposition induced by genotoxic stress. In: Nature Genetics. 2003 ; Vol. 35, No. 3. pp. 219-220.
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