Human Alu element retrotransposition induced by genotoxic stress

Christy R. Hagan; Rebecca F. Sheffield; Charles M. Rudin

doi:10.1038/ng1259

Human Alu element retrotransposition induced by genotoxic stress

Christy R. Hagan, Rebecca F. Sheffield, Charles M. Rudin

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

Original language	English (US)
Pages (from-to)	219-220
Number of pages	2
Journal	Nature Genetics
Volume	35
Issue number	3
DOIs	https://doi.org/10.1038/ng1259
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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10.1038/ng1259

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title = "Human Alu element retrotransposition induced by genotoxic stress",

abstract = "Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).",

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AB - Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

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Human Alu element retrotransposition induced by genotoxic stress

Abstract

ASJC Scopus subject areas

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