HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

Kwanyee Leung, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Like other viruses that infect primate cells, the human T lym-photropic virus-I (HTLV-I) stimulates production of some host cell proteins. In particular, HTLV-I infected T cells synthesize interleukin-2 receptor α (IL-2Rα) chain, which is probably induced through the mediation of the tat-I gene product of the virus1-5. Activated T cells contain a transcription factor called NF-κB6, which stimulates the expression of human immunodeficiency virus-1 (HIV-1) by binding to an 11-base-pair enhancer sequence called κB. We have now found evidence that a similar transcription factor is involved in the induction of IL-2Rα expression by tat-I. We have identified a sequence upstream of IL-2Rα which is the same as the κB site at 9 of 11 base pairs, competes for binding to the κB sequence, and serves as a tat-I responsive element when multiple copies are inserted upstream of a heterologous promoter. The tat-I product also induces κB and the IL-2Rα κB binding activity in transfected Jurkat T lymphoid leukaemia cells. Both HTLV-I and HIV-1 thus interact with NF-κB-like transcription factors which might normally regulate expression of a growth factor receptor gene.

Original languageEnglish (US)
Pages (from-to)776-778
Number of pages3
JournalNature
Volume333
Issue number6175
StatePublished - 1988
Externally publishedYes

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Human T-lymphotropic virus 1
Trans-Activators
Interleukin-2 Receptors
Viruses
Transcription Factors
Base Pairing
HIV-1
tat Gene Products
T-Lymphocytes
Lymphoid Leukemia
Virus Attachment
Growth Factor Receptors
Primates
Lymphocytes
3'-(1-butylphosphoryl)adenosine
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor. / Leung, Kwanyee; Nabel, Gary J.

In: Nature, Vol. 333, No. 6175, 1988, p. 776-778.

Research output: Contribution to journalArticle

Leung, Kwanyee ; Nabel, Gary J. / HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor. In: Nature. 1988 ; Vol. 333, No. 6175. pp. 776-778.
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