HTK preservative solution is associated with increased biliary complications among patients receiving DCD liver transplants: A single center experience

Murat T. Gulsen, Mohit Girotra, Guldane Cengiz-Seval, Jennifer Price, Vikesh Singh, Dorry Segev, Andrew M Cameron, Ahmet Gurakar

Research output: Contribution to journalArticle

Abstract

This study compares biliary complication rates associated with use of two different preservative solutions, Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW), utilized in orthotopic liver transplantation (LT) with donations after cardiac death (DCDs). Between 1997-2010, we retrospectively studied 35 LTs performed utilizing DCD donors, preserved either with HTK (n=17) or UW(n=18). Biliary complications were defined by the presence of anastomotic strictures, non-anastomotic strictures, and/or biliary leak on endoscopic retrograde cholangiopancreatography. HTK and UW cohorts were similar in terms of demographics as well as pre- and post-operative biochemical profile. Donor age was significantly higher among HTK compared to UW recipients (41.5±11.9 vs. 26.2±8.8 years, p

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalAnnals of transplantation : quarterly of the Polish Transplantation Society
Volume18
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Histidine
Tryptophan
Transplants
Liver
Pathologic Constriction
Tissue Donors
Endoscopic Retrograde Cholangiopancreatography
Liver Transplantation
Demography
Bretschneider cardioplegic solution

Keywords

  • Biliary complications
  • DCD
  • HTK
  • Liver transplantation
  • Preservative
  • UW

ASJC Scopus subject areas

  • Transplantation

Cite this

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abstract = "This study compares biliary complication rates associated with use of two different preservative solutions, Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW), utilized in orthotopic liver transplantation (LT) with donations after cardiac death (DCDs). Between 1997-2010, we retrospectively studied 35 LTs performed utilizing DCD donors, preserved either with HTK (n=17) or UW(n=18). Biliary complications were defined by the presence of anastomotic strictures, non-anastomotic strictures, and/or biliary leak on endoscopic retrograde cholangiopancreatography. HTK and UW cohorts were similar in terms of demographics as well as pre- and post-operative biochemical profile. Donor age was significantly higher among HTK compared to UW recipients (41.5±11.9 vs. 26.2±8.8 years, p",
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AU - Price, Jennifer

AU - Singh, Vikesh

AU - Segev, Dorry

AU - Cameron, Andrew M

AU - Gurakar, Ahmet

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