H215O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans

Frank Q. Ye, Karen Faith Berman, Timothy Ellmore, Giuseppe Esposito, John D. Van Horn, Yihong Yang, Jeff Duyn, Anne M. Smith, Joseph A. Frank, Daniel R. Weinberger, Alan C. McLaughlin

Research output: Contribution to journalArticlepeer-review

Abstract

Steady-state arterial spin tagging approaches can provide quantitative images of CBF, but have not been validated in humans. The work presented here compared CBF values measured using steady-state arterial spin tagging with CBF values measured in the same group of human subjects using the H215O IV bolus PET method. Blood flow values determined by H215O PET were corrected for the known effects of incomplete extraction of water across the blood brain barrier. For a cortical strip ROI, blood flow values determined using arterial spin tagging (64 ± 12 cc/100g/min) were not statistically different from corrected blood flow values determined using H215O PET (67 ± 13 cc/100g/min). However, for a central white matter ROI, blood flow values determined using arterial spin tagging were significantly understimated compared to corrected blood flow values determined using H215O PET. This underestimation could be caused by an underestimation of the arterial transit time for white matter regions.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalMagnetic resonance in medicine
Volume44
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Arterial spin tagging
  • CBF
  • H5O
  • MRI
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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