H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine γ-lyase

Guangdong Yang, Lingyun Wu, Bo Jiang, Wei Yang, Jiansong Qi, Kun Cao, Qinghe Meng, Asif K. Mustafa, Weitong Mu, Shengming Zhang, Solomon H. Snyder, Rui Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalScience
Volume322
Issue number5901
DOIs
StatePublished - Oct 24 2008

ASJC Scopus subject areas

  • General

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