H2S: A Novel Gasotransmitter that Signals by Sulfhydration

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154 Scopus citations


Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.

Original languageEnglish (US)
Pages (from-to)687-700
Number of pages14
JournalTrends in biochemical sciences
Issue number11
StatePublished - 2015


  • Cysteine
  • Gasotransmitter
  • Hydrogen sulfide
  • Sulfhydration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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