H2S: A Novel Gasotransmitter that Signals by Sulfhydration

Research output: Contribution to journalArticle

Abstract

Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S. Hydrogen sulfide (H2S) is a gasotransmitter that signals via sulfhydration, a post-translational modification.Sulfhydration occurs on reactive cysteine residues and converts the Cys -SH group to an -SSH group.Sulfhydration modulates diverse physiological processes ranging from regulation of blood pressure to signaling in the nervous system.An emerging theme is the interplay of sulfhydration and nitrosylation that fine tunes signaling pathways.A variety of detection agents for H2S and sulfhydration have been developed to study the role of this modification in physiological systems.

Original languageEnglish (US)
JournalTrends in Biochemical Sciences
DOIs
StateAccepted/In press - 2015

Fingerprint

Gasotransmitters
Physiological Phenomena
Hydrogen Sulfide
Blood pressure
Post Translational Protein Processing
Blood Pressure
Mammals
Neurology
Atmosphere
Nervous System
Cysteine
Molecules
Proteins

Keywords

  • Cysteine
  • Gasotransmitter
  • Hydrogen sulfide
  • Sulfhydration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

@article{72cef6bae2264005abfa6cb05e03f6e1,
title = "H2S: A Novel Gasotransmitter that Signals by Sulfhydration",
abstract = "Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S. Hydrogen sulfide (H2S) is a gasotransmitter that signals via sulfhydration, a post-translational modification.Sulfhydration occurs on reactive cysteine residues and converts the Cys -SH group to an -SSH group.Sulfhydration modulates diverse physiological processes ranging from regulation of blood pressure to signaling in the nervous system.An emerging theme is the interplay of sulfhydration and nitrosylation that fine tunes signaling pathways.A variety of detection agents for H2S and sulfhydration have been developed to study the role of this modification in physiological systems.",
keywords = "Cysteine, Gasotransmitter, Hydrogen sulfide, Sulfhydration",
author = "Bindu Paul and Snyder, {Solomon H}",
year = "2015",
doi = "10.1016/j.tibs.2015.08.007",
language = "English (US)",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - H2S

T2 - A Novel Gasotransmitter that Signals by Sulfhydration

AU - Paul, Bindu

AU - Snyder, Solomon H

PY - 2015

Y1 - 2015

N2 - Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S. Hydrogen sulfide (H2S) is a gasotransmitter that signals via sulfhydration, a post-translational modification.Sulfhydration occurs on reactive cysteine residues and converts the Cys -SH group to an -SSH group.Sulfhydration modulates diverse physiological processes ranging from regulation of blood pressure to signaling in the nervous system.An emerging theme is the interplay of sulfhydration and nitrosylation that fine tunes signaling pathways.A variety of detection agents for H2S and sulfhydration have been developed to study the role of this modification in physiological systems.

AB - Hydrogen sulfide (H2S) is a member of the growing family of gasotransmitters. Once regarded as a noxious molecule predominantly present in the atmosphere, H2S is now known to be synthesized endogenously in mammals. H2S participates in a myriad of physiological processes ranging from regulation of blood pressure to neuroprotection. Its chemical nature precludes H2S from being stored in vesicles and acting on receptor proteins in the fashion of other chemical messengers. Thus, novel cellular mechanisms have evolved to mediate its effects. This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S. Hydrogen sulfide (H2S) is a gasotransmitter that signals via sulfhydration, a post-translational modification.Sulfhydration occurs on reactive cysteine residues and converts the Cys -SH group to an -SSH group.Sulfhydration modulates diverse physiological processes ranging from regulation of blood pressure to signaling in the nervous system.An emerging theme is the interplay of sulfhydration and nitrosylation that fine tunes signaling pathways.A variety of detection agents for H2S and sulfhydration have been developed to study the role of this modification in physiological systems.

KW - Cysteine

KW - Gasotransmitter

KW - Hydrogen sulfide

KW - Sulfhydration

UR - http://www.scopus.com/inward/record.url?scp=84945930415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945930415&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2015.08.007

DO - 10.1016/j.tibs.2015.08.007

M3 - Article

C2 - 26439534

AN - SCOPUS:84945930415

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

ER -