HPV vaccination to prevent oropharyngeal carcinoma: What can be learned from anogenital vaccination programs?

Robert P. Takes, Małgorzata Wierzbicka, Gypsyamber D'Souza, Joanna Jackowska, Carl E. Silver, Juan P. Rodrigo, Frederik G. Dikkers, Kerry D. Olsen, Alessandra Rinaldo, Ruud H. Brakenhoff, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

Abstract

Human papillomavirus (HPV) infections are well known causes of anogenital cancers. Recent studies show that HPV also plays a role in oropharyngeal cancer (OPC). A review on the role of HPV vaccination in the prevention of head and neck squamous cell carcinoma (HNSCC) with special emphasis on OPC was conducted and available vaccines and vaccination strategies in HNSCC and OPC are discussed. Prophylactic vaccination is known to be effective for prevention of anogenital HPV infection and precursor lesions in the cervix and anus. While the value of vaccination for prevention of OPC and possibly as an adjuvant treatment is still an open question, evidence to date supports the possibility that HPV vaccination may prove to be effective in reducing the incidence of this malignancy.

Original languageEnglish (US)
Pages (from-to)1057-1060
Number of pages4
JournalOral Oncology
Volume51
Issue number12
DOIs
StatePublished - Dec 2015

Keywords

  • Cancer
  • Head and neck
  • Human papilloma virus
  • Oropharyngeal
  • Vaccination

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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