HPV-associated lung cancers

An international pooled analysis

Camille Ragin, Monisola Obikoya-Malomo, Sungjin Kim, Zhengjia Chen, Rafael Flores-Obando, Denise Gibbs, Chihaya Koriyama, Francisco Aguayo, Jill Koshiol, Neil E. Caporaso, Giovanna E. Carpagnano, Marco Ciotti, Hirotoshi Dosaka-Akita, Masashi Fukayama, Akiteru Goto, Demetrios A. Spandidos, Vassilis Gorgoulis, Daniëlle A M Heideman, Robert A A van Boerdonk, Kenzo Hiroshima & 20 others Reika Iwakawa, Nikolaos G. Kastrinakis, Ichiro Kinoshita, Suminori Akiba, Maria T. Landi, H. Eugene Liu, Jinn Li Wang, Ranee Mehra, Fadlo R. Khuri, Wan Teck Lim, Taofeek K. Owonikoko, Suresh Ramalingam, Emmanuela Sarchianaki, Kari Syrjanen, Ming Sound Tsao, Jenna Sykes, Siew Wan Hee, Jun Yokota, Apostolos Zaravinos, Emanuela Taioli

Research output: Contribution to journalArticle

Abstract

Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of crosssectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.

Original languageEnglish (US)
Pages (from-to)1267-1275
Number of pages9
JournalCarcinogenesis
Volume35
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

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Lung Neoplasms
Lung
North America
Neoplasms
Odds Ratio
Confidence Intervals
Central America
South America
DNA
Uterine Cervical Neoplasms
Histology
Smoking
History
Demography

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ragin, C., Obikoya-Malomo, M., Kim, S., Chen, Z., Flores-Obando, R., Gibbs, D., ... Taioli, E. (2014). HPV-associated lung cancers: An international pooled analysis. Carcinogenesis, 35(6), 1267-1275. https://doi.org/10.1093/carcin/bgu038

HPV-associated lung cancers : An international pooled analysis. / Ragin, Camille; Obikoya-Malomo, Monisola; Kim, Sungjin; Chen, Zhengjia; Flores-Obando, Rafael; Gibbs, Denise; Koriyama, Chihaya; Aguayo, Francisco; Koshiol, Jill; Caporaso, Neil E.; Carpagnano, Giovanna E.; Ciotti, Marco; Dosaka-Akita, Hirotoshi; Fukayama, Masashi; Goto, Akiteru; Spandidos, Demetrios A.; Gorgoulis, Vassilis; Heideman, Daniëlle A M; van Boerdonk, Robert A A; Hiroshima, Kenzo; Iwakawa, Reika; Kastrinakis, Nikolaos G.; Kinoshita, Ichiro; Akiba, Suminori; Landi, Maria T.; Liu, H. Eugene; Wang, Jinn Li; Mehra, Ranee; Khuri, Fadlo R.; Lim, Wan Teck; Owonikoko, Taofeek K.; Ramalingam, Suresh; Sarchianaki, Emmanuela; Syrjanen, Kari; Tsao, Ming Sound; Sykes, Jenna; Hee, Siew Wan; Yokota, Jun; Zaravinos, Apostolos; Taioli, Emanuela.

In: Carcinogenesis, Vol. 35, No. 6, 2014, p. 1267-1275.

Research output: Contribution to journalArticle

Ragin, C, Obikoya-Malomo, M, Kim, S, Chen, Z, Flores-Obando, R, Gibbs, D, Koriyama, C, Aguayo, F, Koshiol, J, Caporaso, NE, Carpagnano, GE, Ciotti, M, Dosaka-Akita, H, Fukayama, M, Goto, A, Spandidos, DA, Gorgoulis, V, Heideman, DAM, van Boerdonk, RAA, Hiroshima, K, Iwakawa, R, Kastrinakis, NG, Kinoshita, I, Akiba, S, Landi, MT, Liu, HE, Wang, JL, Mehra, R, Khuri, FR, Lim, WT, Owonikoko, TK, Ramalingam, S, Sarchianaki, E, Syrjanen, K, Tsao, MS, Sykes, J, Hee, SW, Yokota, J, Zaravinos, A & Taioli, E 2014, 'HPV-associated lung cancers: An international pooled analysis', Carcinogenesis, vol. 35, no. 6, pp. 1267-1275. https://doi.org/10.1093/carcin/bgu038
Ragin C, Obikoya-Malomo M, Kim S, Chen Z, Flores-Obando R, Gibbs D et al. HPV-associated lung cancers: An international pooled analysis. Carcinogenesis. 2014;35(6):1267-1275. https://doi.org/10.1093/carcin/bgu038
Ragin, Camille ; Obikoya-Malomo, Monisola ; Kim, Sungjin ; Chen, Zhengjia ; Flores-Obando, Rafael ; Gibbs, Denise ; Koriyama, Chihaya ; Aguayo, Francisco ; Koshiol, Jill ; Caporaso, Neil E. ; Carpagnano, Giovanna E. ; Ciotti, Marco ; Dosaka-Akita, Hirotoshi ; Fukayama, Masashi ; Goto, Akiteru ; Spandidos, Demetrios A. ; Gorgoulis, Vassilis ; Heideman, Daniëlle A M ; van Boerdonk, Robert A A ; Hiroshima, Kenzo ; Iwakawa, Reika ; Kastrinakis, Nikolaos G. ; Kinoshita, Ichiro ; Akiba, Suminori ; Landi, Maria T. ; Liu, H. Eugene ; Wang, Jinn Li ; Mehra, Ranee ; Khuri, Fadlo R. ; Lim, Wan Teck ; Owonikoko, Taofeek K. ; Ramalingam, Suresh ; Sarchianaki, Emmanuela ; Syrjanen, Kari ; Tsao, Ming Sound ; Sykes, Jenna ; Hee, Siew Wan ; Yokota, Jun ; Zaravinos, Apostolos ; Taioli, Emanuela. / HPV-associated lung cancers : An international pooled analysis. In: Carcinogenesis. 2014 ; Vol. 35, No. 6. pp. 1267-1275.
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abstract = "Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of crosssectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3{\%}, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95{\%} confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95{\%} CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93{\%}, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.",
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T1 - HPV-associated lung cancers

T2 - An international pooled analysis

AU - Ragin, Camille

AU - Obikoya-Malomo, Monisola

AU - Kim, Sungjin

AU - Chen, Zhengjia

AU - Flores-Obando, Rafael

AU - Gibbs, Denise

AU - Koriyama, Chihaya

AU - Aguayo, Francisco

AU - Koshiol, Jill

AU - Caporaso, Neil E.

AU - Carpagnano, Giovanna E.

AU - Ciotti, Marco

AU - Dosaka-Akita, Hirotoshi

AU - Fukayama, Masashi

AU - Goto, Akiteru

AU - Spandidos, Demetrios A.

AU - Gorgoulis, Vassilis

AU - Heideman, Daniëlle A M

AU - van Boerdonk, Robert A A

AU - Hiroshima, Kenzo

AU - Iwakawa, Reika

AU - Kastrinakis, Nikolaos G.

AU - Kinoshita, Ichiro

AU - Akiba, Suminori

AU - Landi, Maria T.

AU - Liu, H. Eugene

AU - Wang, Jinn Li

AU - Mehra, Ranee

AU - Khuri, Fadlo R.

AU - Lim, Wan Teck

AU - Owonikoko, Taofeek K.

AU - Ramalingam, Suresh

AU - Sarchianaki, Emmanuela

AU - Syrjanen, Kari

AU - Tsao, Ming Sound

AU - Sykes, Jenna

AU - Hee, Siew Wan

AU - Yokota, Jun

AU - Zaravinos, Apostolos

AU - Taioli, Emanuela

PY - 2014

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N2 - Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of crosssectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.

AB - Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of crosssectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship.

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