How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

Chien Feng Kuo; Leiyu Shi; Cheng Li Lin; Wei Cheng Yao; Hsiang Ting Chen; Chon Fu Lio; Yu Ting Tina Wang; Ching Huang Su; Nai Wei Hsu; Shin Yi Tsai

doi:10.1038/s41598-021-87018-z

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

Chien Feng Kuo, Leiyu Shi, Cheng Li Lin, Wei Cheng Yao, Hsiang Ting Chen, Chon Fu Lio, Yu Ting Tina Wang, Ching Huang Su, Nai Wei Hsu, Shin Yi Tsai

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.

Original language	English (US)
Article number	7520
Journal	Scientific reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-87018-z
State	Published - Dec 2021

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@article{ce2de2fcff294a4d92a68ddeae9e2910,

title = "How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight",

abstract = "Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.",

author = "Kuo, {Chien Feng} and Leiyu Shi and Lin, {Cheng Li} and Yao, {Wei Cheng} and Chen, {Hsiang Ting} and Lio, {Chon Fu} and Wang, {Yu Ting Tina} and Su, {Ching Huang} and Hsu, {Nai Wei} and Tsai, {Shin Yi}",

note = "Funding Information: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (C.-L.L., grant number MOHW 109-TDU-B-212–114004); MOST Clinical Trial Consortium for Stroke (C.-L.L., grant number MOST 108–2321-B-039–003-); Tseng-Lien Lin Foundation, Taichung, Taiwan (C.-L.L.); the Department of Medical Research at Mackay Memorial Hospital, Taiwan (S.-Y. T., grant number MMH-106–81), (S.-Y. T., grant number MMH-107–71), (S.-Y. T., grant number MMH-107–102), (S.-Y. T., grant number MMH-107–135), (S.-Y. T., grant number MMH-109–103) and Mackay Medical College (S.-Y. T., grant number MMC1082A03). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The APC was funded by the Department of Medical Research at Mackay Memorial Hospital and Corresponding author: Dr. Shin-Yi Tsai. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41598-021-87018-z",

language = "English (US)",

volume = "11",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

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TY - JOUR

T1 - How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome

T2 - an insight

AU - Kuo, Chien Feng

AU - Shi, Leiyu

AU - Lin, Cheng Li

AU - Yao, Wei Cheng

AU - Chen, Hsiang Ting

AU - Lio, Chon Fu

AU - Wang, Yu Ting Tina

AU - Su, Ching Huang

AU - Hsu, Nai Wei

AU - Tsai, Shin Yi

N1 - Funding Information: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (C.-L.L., grant number MOHW 109-TDU-B-212–114004); MOST Clinical Trial Consortium for Stroke (C.-L.L., grant number MOST 108–2321-B-039–003-); Tseng-Lien Lin Foundation, Taichung, Taiwan (C.-L.L.); the Department of Medical Research at Mackay Memorial Hospital, Taiwan (S.-Y. T., grant number MMH-106–81), (S.-Y. T., grant number MMH-107–71), (S.-Y. T., grant number MMH-107–102), (S.-Y. T., grant number MMH-107–135), (S.-Y. T., grant number MMH-109–103) and Mackay Medical College (S.-Y. T., grant number MMC1082A03). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The APC was funded by the Department of Medical Research at Mackay Memorial Hospital and Corresponding author: Dr. Shin-Yi Tsai. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.

AB - Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.

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How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

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