How MHC class II molecules work: peptide-dependent completion of protein folding

Scheherazade Sadegh-Nasseri, Ronald N. Germain

Research output: Contribution to journalArticlepeer-review

Abstract

It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalImmunology Today
Volume13
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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