TY - JOUR
T1 - How MHC class II molecules work
T2 - peptide-dependent completion of protein folding
AU - Sadegh-Nasseri, Scheherazade
AU - Germain, Ronald N.
PY - 1992
Y1 - 1992
N2 - It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.
AB - It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.
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U2 - 10.1016/0167-5699(92)90131-P
DO - 10.1016/0167-5699(92)90131-P
M3 - Article
C2 - 1533524
AN - SCOPUS:0026584496
SN - 0167-5699
VL - 13
SP - 43
EP - 46
JO - Immunology Today
JF - Immunology Today
IS - 2
ER -