How liquid biopsies can change clinical practice in oncology

G. Siravegna, B. Mussolin, T. Venesio, S. Marsoni, J. Seoane, C. Dive, N. Papadopoulos, S. Kopetz, R. B. Corcoran, L. L. Siu, A. Bardelli

Research output: Contribution to journalReview article

Abstract

Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including preanalytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice: by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent.

Original languageEnglish (US)
Pages (from-to)1580-1590
Number of pages11
JournalAnnals of Oncology
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2019

Keywords

  • cancer diagnosis
  • circulating free DNA
  • clonal evolution
  • liquid biopsy
  • minimal residual disease
  • resistance

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'How liquid biopsies can change clinical practice in oncology'. Together they form a unique fingerprint.

  • Cite this

    Siravegna, G., Mussolin, B., Venesio, T., Marsoni, S., Seoane, J., Dive, C., Papadopoulos, N., Kopetz, S., Corcoran, R. B., Siu, L. L., & Bardelli, A. (2019). How liquid biopsies can change clinical practice in oncology. Annals of Oncology, 30(10), 1580-1590. https://doi.org/10.1093/annonc/mdz227