How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity

Scheherazade Sadegh-Nasseri, Chih Ling Chou, Isamu Z. Hartman, Aeryon Kim, Kedar Narayan

Research output: Contribution to journalArticle

Abstract

Helper T cells respond to peptide antigens derived from exogenous sources presented by MHC II on antigen presenting cells. Antigens from pathogens are internalized by professional antigen presenting cells (APC) and processed for presentation. Certain epitopes are selected during processing as the final peptides for stimulation of T cells and are termed "immunodominant". Understanding how selection of immunodominant epitopes takes place has been a difficult task because of the complexity of the mechanisms governing both antigen processing and T cell recognition. In this review, we discuss our current understanding of HLA-DM function in peptide exchange and selection and its relevance to epitope immunodominance.

Original languageEnglish (US)
Pages (from-to)1325-1332
Number of pages8
JournalFrontiers in Bioscience - Scholar
Volume4 S
Issue number4
DOIs
StatePublished - Jun 1 2012

Keywords

  • Antigen presentation
  • Antigen processing
  • Conformational heterogeneity
  • Epitope selection
  • HLA-DM
  • HLA-DR
  • Immunodominance
  • MHC class II
  • Molecular recognition
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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