Abstract
A small percentage of people living with HIV-1 can control viral replication without antiretroviral therapy (ART). These patients are called elite controllers (ECs) if they are able to maintain viral suppression without initiating ART and posttreatment controllers (PTCs) if they control HIV replication after ART has been discontinued. Both types of controllers may serve as a model of a functional cure for HIV-1 but the mechanisms responsible for viral control have not been fully elucidated. In this review, we highlight key lessons that have been learned so far in the study of ECs and PTCs and their implications for HIV cure research.
Original language | English (US) |
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Article number | e149414 |
Journal | Journal of Clinical Investigation |
Volume | 131 |
Issue number | 11 |
DOIs | |
State | Published - Jun 2021 |
ASJC Scopus subject areas
- General Medicine