How does your kidney smell? Emerging roles for olfactory receptors in renal function

Blythe D. Shepard, Jennifer L. Pluznick

Research output: Contribution to journalReview article

Abstract

Olfactory receptors (ORs) are chemosensors that are responsible for one’s sense of smell. In addition to this specialized role in the nose, recent evidence suggests that ORs are also found in a variety of additional tissues including the kidney. As this list of renal ORs continues to expand, it is becoming clear that they play important roles in renal and whole-body physiology, including a novel role in blood pressure regulation. In this review, we highlight important considerations that are crucial when studying ORs and present the current literature on renal ORs and their emerging relevance in maintaining renal function.

Original languageEnglish (US)
Pages (from-to)715-723
Number of pages9
JournalPediatric Nephrology
Volume31
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • Adenylate cyclase 3
  • Blood pressure
  • Kidney
  • Ligand
  • Odorant receptor
  • Olfactory receptors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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