Hostility predicts recurrent events among postmenopausal women with coronary heart disease

Lily A. Chaput, Sally H. Adams, Joel A. Simon, Roger S Blumenthal, Eric Vittinghoff, Feng Lin, Evan Loh, Karen A. Matthews

Research output: Contribution to journalArticle

Abstract

Psychosocial characteristics may be associated with an increased risk of coronary heart disease (CHD). Whether hostility predicts recurrent coronary events is unknown. A total of 792 women in the Heart and Estrogen/progestin Replacement Study (HERS) were evaluated prospectively to determine the role of hostility as a risk factor for secondary CHD events (nonfatal myocardial infarction and CHD death). The mean age of study participants was 67 years, and the average length of follow-up was 4.1 years. The study was conducted between 1993 and 1998, and all study sites were in the United States. High Cook-Medley hostility scores were associated with greater body mass index (p = 0.01) and higher levels of serum triglycerides (p = 0.05), and they were inversely associated with high density lipoprotein cholesterol (p = 0.04), self-rated general health (p <0.001), age (p = 0.05), and education (p = 0.001). Compared with women in the lowest hostility score quartile, women in the highest quartile were twice as likely to have had a myocardial infarction (relative hazard = 2.03, 95% confidence interval: 1.02, 4.01). The relation between hostility and CHD events was not mediated or confounded by the biologic, behavioral, and social risk factors studied. In this study, hostility was found to be an independent risk factor for recurrent CHD events in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1092-1099
Number of pages8
JournalAmerican Journal of Epidemiology
Volume156
Issue number12
DOIs
StatePublished - Dec 15 2002

Fingerprint

Hostility
Coronary Disease
Myocardial Infarction
Estrogen Replacement Therapy
Progestins
HDL Cholesterol
Triglycerides
Body Mass Index
Confidence Intervals
Education
Health
Serum

Keywords

  • Coronary disease
  • Hostility
  • Postmenopause
  • Risk factors
  • Women

ASJC Scopus subject areas

  • Epidemiology

Cite this

Chaput, L. A., Adams, S. H., Simon, J. A., Blumenthal, R. S., Vittinghoff, E., Lin, F., ... Matthews, K. A. (2002). Hostility predicts recurrent events among postmenopausal women with coronary heart disease. American Journal of Epidemiology, 156(12), 1092-1099. https://doi.org/10.1093/aje/kwf158

Hostility predicts recurrent events among postmenopausal women with coronary heart disease. / Chaput, Lily A.; Adams, Sally H.; Simon, Joel A.; Blumenthal, Roger S; Vittinghoff, Eric; Lin, Feng; Loh, Evan; Matthews, Karen A.

In: American Journal of Epidemiology, Vol. 156, No. 12, 15.12.2002, p. 1092-1099.

Research output: Contribution to journalArticle

Chaput, LA, Adams, SH, Simon, JA, Blumenthal, RS, Vittinghoff, E, Lin, F, Loh, E & Matthews, KA 2002, 'Hostility predicts recurrent events among postmenopausal women with coronary heart disease', American Journal of Epidemiology, vol. 156, no. 12, pp. 1092-1099. https://doi.org/10.1093/aje/kwf158
Chaput, Lily A. ; Adams, Sally H. ; Simon, Joel A. ; Blumenthal, Roger S ; Vittinghoff, Eric ; Lin, Feng ; Loh, Evan ; Matthews, Karen A. / Hostility predicts recurrent events among postmenopausal women with coronary heart disease. In: American Journal of Epidemiology. 2002 ; Vol. 156, No. 12. pp. 1092-1099.
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