@inbook{0fa1da8f47994985824f152da7563154,
title = "Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif",
abstract = "The arms race between virus and host is a constant battle. APOBEC3 proteins are known to be potent innate cellular defenses against both endogenous retroelements and diverse retroviruses. However, retroviruses have developed their own methods to launch counter-strikes. Most primate lentiviruses encode a protein called the viral infectivity factor (Vif). Vif induces targeted destruction of APOBEC3 proteins by hijacking the cellular ubiquitin-proteasome pathway. Here we review the research that led up to the identification of A3G, the mechanisms by which APOBEC3 proteins can inhibit retroelements, and the counter-mechanisms that HIV-1 Vif has developed to evade its antiviral activities.",
author = "Niewiadomska, {Anna Maria} and Yu, {Xiao Fang}",
note = "Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2009",
doi = "10.1007/978-3-642-02175-6_1",
language = "English (US)",
isbn = "9783642021749",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Verlag",
number = "1",
pages = "1--25",
booktitle = "HIV Interactions with Host Cell Proteins",
edition = "1",
}