Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif

Anna Maria Niewiadomska, Xiao Fang Yu

Research output: Contribution to journalArticle

Abstract

The arms race between virus and host is a constant battle. APOBEC3 proteins are known to be potent innate cellular defenses against both endogenous retroelements and diverse retroviruses. However, retroviruses have developed their own methods to launch counter-strikes. Most primate lentiviruses encode a protein called the viral infectivity factor (Vif). Vif induces targeted destruction of APOBEC3 proteins by hijacking the cellular ubiquitin-proteasome pathway. Here we review the research that led up to the identification of A3G, the mechanisms by which APOBEC3 proteins can inhibit retroelements, and the counter-mechanisms that HIV-1 Vif has developed to evade its antiviral activities.

Original languageEnglish (US)
Pages (from-to)1-25
Number of pages25
JournalCurrent Topics in Microbiology and Immunology
Volume339
Issue number1
DOIs
StatePublished - 2009

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HIV-1
Retroelements
Retroviridae
Primate Lentiviruses
Proteins
Viral Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Antiviral Agents
Viruses
Research

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif. / Niewiadomska, Anna Maria; Yu, Xiao Fang.

In: Current Topics in Microbiology and Immunology, Vol. 339, No. 1, 2009, p. 1-25.

Research output: Contribution to journalArticle

Niewiadomska, Anna Maria ; Yu, Xiao Fang. / Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif. In: Current Topics in Microbiology and Immunology. 2009 ; Vol. 339, No. 1. pp. 1-25.
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