Host response to Mycobacterium tuberculosis.

Z. Toossi, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Critical to the complete expression of the virulence of M. tuberculosis and thereby its pathogenesis in human infection, is the ability of this pathogen to interact with the host in a specific manner. To date, cytokine circuits during tuberculosis and M. tuberculosis infection have been studied most intensely. With this regard, both the whole M. tuberculosis and its protein and non-protein moieties appear to be influential on the in situ cytokine profile, and consequently, to the final outcome of infection. The interplay and final balance of macrophage activating and immuno-enhancing cytokines versus macrophage deactivating and immunosuppressive cytokines most likely determines the final expression of M. tuberculosis infection. Further, cytokine circuits also underlie the immunopathology of tuberculosis. Modulation of the in vivo cytokine milieu may allow the development of more effective vaccines to prevent M. tuberculosis infection, and adjunctive immunotherapy to improve treatment of tuberculosis.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume3
StatePublished - 1998
Externally publishedYes

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Mycobacterium tuberculosis
Cytokines
Mycobacterium Infections
Tuberculosis
Macrophages
Networks (circuits)
Pathogens
Immunosuppressive Agents
Infection
Immunotherapy
Virulence
Vaccines
Modulation
Proteins

Cite this

Host response to Mycobacterium tuberculosis. / Toossi, Z.; Ellner, J. J.

In: Frontiers in bioscience : a journal and virtual library, Vol. 3, 1998.

Research output: Contribution to journalArticle

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