Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair

Maryellen Sandor, Hui Xu, Jerome Connor, Jared Lombardi, John R. Harper, Ronald P. Silverman, David J. McQuillan

Research output: Contribution to journalArticle

Abstract

Three commercially available porcine-derived biologic meshes were implanted in an Old World primate abdominal wall resection repair model to compare biological outcome as a predictor of clinical efficacy. Tissues were explanted over a 6-month period and evaluated for gross pathology, wound healing strength, mesenchymal cellular repopulation, vascularity, and immune response. In vivo functional outcomes were correlated with in vitro profile for each material. Small intestinal submucosa-based implants demonstrated scar tissue formation and contraction, coincident with mesh pleating, and were characterized by immediate and significant cellular and humoral inflammatory responses. Porcine dermal-based grafts demonstrated significant graft pleating, minimal integration, and an absence of cellular repopulation and vascularization. However, a significant cellular immune response surrounded the grafts, coincident with poor initial wound healing strengths. In vivo observations for the three porcine-derived mesh products correlated with individual in vitro profiles, indicating an absence of characteristic biochemical markers and structural integrity. This correlation suggests that in vivo results observed for these mesh products are a direct consequence of specific manufacturing processes that yield modified collagen matrices. The resulting loss of biological and structural integrity elicits a foreign body response while hindering normal healing and tissue integration.

Original languageEnglish (US)
Pages (from-to)2021-2031
Number of pages11
JournalTissue Engineering - Part A
Volume14
Issue number12
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Abdominal Wall
Grafts
Primates
Repair
Swine
Structural integrity
Tissue
Transplants
Wound Healing
Pathology
Foreign Bodies
Collagen
Cellular Immunity
Cicatrix
Biomarkers
Skin
In Vitro Techniques

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials

Cite this

Sandor, M., Xu, H., Connor, J., Lombardi, J., Harper, J. R., Silverman, R. P., & McQuillan, D. J. (2008). Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair. Tissue Engineering - Part A, 14(12), 2021-2031. https://doi.org/10.1089/ten.tea.2007.0317

Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair. / Sandor, Maryellen; Xu, Hui; Connor, Jerome; Lombardi, Jared; Harper, John R.; Silverman, Ronald P.; McQuillan, David J.

In: Tissue Engineering - Part A, Vol. 14, No. 12, 01.11.2008, p. 2021-2031.

Research output: Contribution to journalArticle

Sandor, M, Xu, H, Connor, J, Lombardi, J, Harper, JR, Silverman, RP & McQuillan, DJ 2008, 'Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair', Tissue Engineering - Part A, vol. 14, no. 12, pp. 2021-2031. https://doi.org/10.1089/ten.tea.2007.0317
Sandor, Maryellen ; Xu, Hui ; Connor, Jerome ; Lombardi, Jared ; Harper, John R. ; Silverman, Ronald P. ; McQuillan, David J. / Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair. In: Tissue Engineering - Part A. 2008 ; Vol. 14, No. 12. pp. 2021-2031.
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