Host Genetic Factors and Antiviral Immune Responses to Hepatitis C Virus

Chloe L. Thio

doi:10.1016/j.cld.2008.03.002

Host Genetic Factors and Antiviral Immune Responses to Hepatitis C Virus

Chloe L. Thio

School of Medicine

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Human genome variations explain some of the heterogeneity in the immune response to antigenic stimuli. Such differences in response to hepatitis C virus (HCV) antigens can account for the ability of the immune response to clear HCV after an acute infection or to develop more rapidly progressive liver disease. Several studies have examined polymorphisms in several candidate immune-response genes for their relation to these HCV outcomes. Results of some of these studies complement knowledge gained from immunology studies, and others offer new insights into HCV biology. This review summarizes published studies on variation in immune-response genes and HCV outcomes.

Original language	English (US)
Pages (from-to)	713-726
Number of pages	14
Journal	Clinics in Liver Disease
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2008.03.002
State	Published - Aug 2008

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2008.03.002

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title = "Host Genetic Factors and Antiviral Immune Responses to Hepatitis C Virus",

abstract = "Human genome variations explain some of the heterogeneity in the immune response to antigenic stimuli. Such differences in response to hepatitis C virus (HCV) antigens can account for the ability of the immune response to clear HCV after an acute infection or to develop more rapidly progressive liver disease. Several studies have examined polymorphisms in several candidate immune-response genes for their relation to these HCV outcomes. Results of some of these studies complement knowledge gained from immunology studies, and others offer new insights into HCV biology. This review summarizes published studies on variation in immune-response genes and HCV outcomes.",

author = "Thio, {Chloe L.}",

note = "Funding Information: This work was supported by National Institutes of Health grant DA 13324 and the Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases Award. ",

year = "2008",

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AU - Thio, Chloe L.

N1 - Funding Information: This work was supported by National Institutes of Health grant DA 13324 and the Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases Award.

PY - 2008/8

Y1 - 2008/8

N2 - Human genome variations explain some of the heterogeneity in the immune response to antigenic stimuli. Such differences in response to hepatitis C virus (HCV) antigens can account for the ability of the immune response to clear HCV after an acute infection or to develop more rapidly progressive liver disease. Several studies have examined polymorphisms in several candidate immune-response genes for their relation to these HCV outcomes. Results of some of these studies complement knowledge gained from immunology studies, and others offer new insights into HCV biology. This review summarizes published studies on variation in immune-response genes and HCV outcomes.

AB - Human genome variations explain some of the heterogeneity in the immune response to antigenic stimuli. Such differences in response to hepatitis C virus (HCV) antigens can account for the ability of the immune response to clear HCV after an acute infection or to develop more rapidly progressive liver disease. Several studies have examined polymorphisms in several candidate immune-response genes for their relation to these HCV outcomes. Results of some of these studies complement knowledge gained from immunology studies, and others offer new insights into HCV biology. This review summarizes published studies on variation in immune-response genes and HCV outcomes.

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JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 3

ER -

Host Genetic Factors and Antiviral Immune Responses to Hepatitis C Virus

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