Host genetic determinants of spontaneous hepatitis C clearance

Andri Rauch, Silvana Gaudieri, Chloe Thio, Pierre Yves Bochud

Research output: Contribution to journalArticle

Abstract

Acute infection with the hepatitis C virus (HCV) induces a wide range of innate and adaptive immune responses. A total of 20-50% of acutely HCV-infected individuals permanently control the virus, referred to as 'spontaneous hepatitis C clearance', while the infection progresses to chronic hepatitis C in the majority of cases. Numerous studies have examined host genetic determinants of hepatitis C infection outcome and revealed the influence of genetic polymorphisms of human leukocyte antigens, killer immunoglobulin-like receptors, chemokines, interleukins and interferon-stimulated genes on spontaneous hepatitis C clearance. However, most genetic associations were not confirmed in independent cohorts, revealed opposing results in diverse populations or were limited by varying definitions of hepatitis C outcomes or small sample size. Coordinated efforts are needed in the search for key genetic determinants of spontaneous hepatitis C clearance that include well-conducted candidate genetic and genome-wide association studies, direct sequencing and follow-up functional studies.

Original languageEnglish (US)
Pages (from-to)1819-1837
Number of pages19
JournalPharmacogenomics
Volume10
Issue number11
DOIs
StatePublished - Dec 2 2009

Keywords

  • Association studies
  • Genetics
  • Hepatitis C
  • Spontaneous hepatitis C clearance

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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