Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

Robert W. Buckheit, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F Siliciano, Joel N Blankson

Research output: Contribution to journalArticle

Abstract

Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.

Original languageEnglish (US)
Article number1697
JournalNature Communications
Volume3
DOIs
StatePublished - 2012

Fingerprint

human immunodeficiency virus
suppressors
HIV-1
controllers
Controllers
infectious diseases
Immunologic Factors
Viruses
viruses
HIV Infections
Vaccination
causes
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs. / Buckheit, Robert W.; Allen, Tracy G.; Alme, Angela; Salgado, Maria; O'Connell, Karen A.; Huculak, Sarah; Falade-Nwulia, Oluwaseun; Williams, Thomas M.; Gallant, Joel E.; Siliciano, Robert F; Blankson, Joel N.

In: Nature Communications, Vol. 3, 1697, 2012.

Research output: Contribution to journalArticle

Buckheit, Robert W. ; Allen, Tracy G. ; Alme, Angela ; Salgado, Maria ; O'Connell, Karen A. ; Huculak, Sarah ; Falade-Nwulia, Oluwaseun ; Williams, Thomas M. ; Gallant, Joel E. ; Siliciano, Robert F ; Blankson, Joel N. / Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs. In: Nature Communications. 2012 ; Vol. 3.
@article{b7a1965984c74948822ad9757a7a8204,
title = "Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs",
abstract = "Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.",
author = "Buckheit, {Robert W.} and Allen, {Tracy G.} and Angela Alme and Maria Salgado and O'Connell, {Karen A.} and Sarah Huculak and Oluwaseun Falade-Nwulia and Williams, {Thomas M.} and Gallant, {Joel E.} and Siliciano, {Robert F} and Blankson, {Joel N}",
year = "2012",
doi = "10.1038/ncomms1697",
language = "English (US)",
volume = "3",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

AU - Buckheit, Robert W.

AU - Allen, Tracy G.

AU - Alme, Angela

AU - Salgado, Maria

AU - O'Connell, Karen A.

AU - Huculak, Sarah

AU - Falade-Nwulia, Oluwaseun

AU - Williams, Thomas M.

AU - Gallant, Joel E.

AU - Siliciano, Robert F

AU - Blankson, Joel N

PY - 2012

Y1 - 2012

N2 - Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.

AB - Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.

UR - http://www.scopus.com/inward/record.url?scp=84859167158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859167158&partnerID=8YFLogxK

U2 - 10.1038/ncomms1697

DO - 10.1038/ncomms1697

M3 - Article

C2 - 22395607

AN - SCOPUS:84859167158

VL - 3

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1697

ER -