Host factors associated with serologic inflammatory markers assessed using multiplex assays

Heather S. McKay, Jay H. Bream, Joseph B. Margolick, Otoniel Martínez-Maza, John P. Phair, Charles R. Rinaldo, Alison G. Abraham, Lisa P. Jacobson

Research output: Research - peer-reviewArticle

Abstract

Chronic systemic inflammation contributes to the development of adverse health conditions, yet the influence of fixed and modifiable risk factors on many serologic biomarkers of inflammation remains largely unknown. Serum concentrations of twenty-three biomarkers, including C-reactive protein (CRP), cytokines (CXCL11, CXCL8, CXCL10, CCL2, CCL13, CCL4, CCL17, CXCL13, IL-10, IL-12p70, IL-6, TNF-α, IL-2, IFN-γ, IL-1β, GM-CSF, BAFF), and soluble immune receptors (sCD14, sIL-2Rα, sCD27, sgp130, sTNF-R2) were measured longitudinally using multiplexed immunometric assays in 250 HIV-uninfected men followed in the Multicenter AIDS Cohort Study (1984-2009). Generalized gamma regression was used to determine the statistical significance of factors associated with each biomarker. After accounting for age, race, and education, and for analysis of multiple biomarkers, higher concentrations of specific individual biomarkers were significantly (P <0.002) associated with hypertension, obesity, hepatitis C infection, stimulant use, and diabetes and lower concentrations with hypercholesterolemia. These associations should be taken into account in epidemiological studies of these biomarkers, and may provide potential targets for disease prevention and treatment.

LanguageEnglish (US)
Pages71-79
Number of pages9
JournalCytokine
Volume85
DOIs
StatePublished - Sep 1 2016

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Biomarkers
Assays
Inflammation
Cytokine Receptor gp130
Granulocyte-Macrophage Colony-Stimulating Factor
Hepatitis C
Hypercholesterolemia
Interleukin-10
C-Reactive Protein
Interleukin-2
Epidemiologic Studies
Interleukin-6
Acquired Immunodeficiency Syndrome
Cohort Studies
Tumor Necrosis Factor-alpha
Obesity
HIV
Cytokines
Hypertension
Education

Keywords

  • C-reactive protein
  • Chemokines
  • Cytokine receptors
  • Cytokines
  • Immune activation
  • Risk factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Host factors associated with serologic inflammatory markers assessed using multiplex assays. / McKay, Heather S.; Bream, Jay H.; Margolick, Joseph B.; Martínez-Maza, Otoniel; Phair, John P.; Rinaldo, Charles R.; Abraham, Alison G.; Jacobson, Lisa P.

In: Cytokine, Vol. 85, 01.09.2016, p. 71-79.

Research output: Research - peer-reviewArticle

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