Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis

Theodouli Stergiopoulou, Joseph Meletiadis, Emmanuel Roilides, David E. Kleiner, R. Schaufele, Maureen Roden, Susan Harrington, Luqman Dad, Brahm Segal, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in neutropenic, nonneutropenic, and other immunocompromised patients. We therefore compared the patterns of infection and inflammation among 3 cohorts of immunocompromised patients with profound neutropenia, nonneutropenic immunosuppression, and hematopoietic stem cell transplantation. Lesions of IPA in neutropenic patients and hematopoietic stem cell transplant (HSCT) recipients were similar and consisted predominantly of angioinvasion and intra-alveolar hemorrhage. The frequency of these histologic findings in neutropenic patients and HSCT recipients differed significantly from those of nonneutropenic patients (P <.05). It is noteworthy that even if HSCT recipients have normal peripheral blood neutrophil counts, there may be no influx into sites of infection. In the nonneutropenic cohort, lesions of IPA consisted mainly of neutrophilic and monocytic infiltrates and inflammatory necrosis. Thus, the status of innate host defenses contributes significantly to the histologic patterns observed in IPA.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

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Invasive Pulmonary Aspergillosis
Hematopoietic Stem Cells
Wounds and Injuries
Immunocompromised Host
Transplants
Hematopoietic Stem Cell Transplantation
Infection
Neutropenia
Immunosuppression
Neutrophils
Necrosis
Hemorrhage
Inflammation
Morbidity
Mortality
Transplant Recipients

Keywords

  • Angioinvasion
  • Corticosteroids
  • Hematopoietic stem cell transplant recipients
  • Invasive pulmonary aspergillosis
  • Neutropenia
  • Pulmonary infarct

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Stergiopoulou, T., Meletiadis, J., Roilides, E., Kleiner, D. E., Schaufele, R., Roden, M., ... Walsh, T. J. (2007). Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. American Journal of Clinical Pathology, 127(3), 349-355. https://doi.org/10.1309/UJRV9DLC11RM3G8R

Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. / Stergiopoulou, Theodouli; Meletiadis, Joseph; Roilides, Emmanuel; Kleiner, David E.; Schaufele, R.; Roden, Maureen; Harrington, Susan; Dad, Luqman; Segal, Brahm; Walsh, Thomas J.

In: American Journal of Clinical Pathology, Vol. 127, No. 3, 03.2007, p. 349-355.

Research output: Contribution to journalArticle

Stergiopoulou, T, Meletiadis, J, Roilides, E, Kleiner, DE, Schaufele, R, Roden, M, Harrington, S, Dad, L, Segal, B & Walsh, TJ 2007, 'Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis', American Journal of Clinical Pathology, vol. 127, no. 3, pp. 349-355. https://doi.org/10.1309/UJRV9DLC11RM3G8R
Stergiopoulou T, Meletiadis J, Roilides E, Kleiner DE, Schaufele R, Roden M et al. Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. American Journal of Clinical Pathology. 2007 Mar;127(3):349-355. https://doi.org/10.1309/UJRV9DLC11RM3G8R
Stergiopoulou, Theodouli ; Meletiadis, Joseph ; Roilides, Emmanuel ; Kleiner, David E. ; Schaufele, R. ; Roden, Maureen ; Harrington, Susan ; Dad, Luqman ; Segal, Brahm ; Walsh, Thomas J. / Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. In: American Journal of Clinical Pathology. 2007 ; Vol. 127, No. 3. pp. 349-355.
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