Abstract
Mucormycosis is a devastating disease and can occur in patients with a variety of risk factors, the most important of which are immunosuppression, anatomic barrier breakdown, iron overload, and hyperglycemia/acidosis. Similarly to what occurs with Aspergillus, the host stimulates an innate immune response against the challenging sporangiospores and invading hyphae of Zygomycetes. This article discusses the host defense to different Zygomycetes, its augmentation, and its subsequent impact on the outcome of mucormycosis.
| Original language | English (US) |
|---|---|
| Journal | Clinical Infectious Diseases |
| Volume | 54 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - Feb 1 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
Cite this
Host defenses against zygomycetes. / Roilides, Emmanuel; Kontoyiannis, Dimitrios P.; Walsh, Thomas J.
In: Clinical Infectious Diseases, Vol. 54, No. SUPPL. 1, 01.02.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Host defenses against zygomycetes
AU - Roilides, Emmanuel
AU - Kontoyiannis, Dimitrios P.
AU - Walsh, Thomas J.
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Mucormycosis is a devastating disease and can occur in patients with a variety of risk factors, the most important of which are immunosuppression, anatomic barrier breakdown, iron overload, and hyperglycemia/acidosis. Similarly to what occurs with Aspergillus, the host stimulates an innate immune response against the challenging sporangiospores and invading hyphae of Zygomycetes. This article discusses the host defense to different Zygomycetes, its augmentation, and its subsequent impact on the outcome of mucormycosis.
AB - Mucormycosis is a devastating disease and can occur in patients with a variety of risk factors, the most important of which are immunosuppression, anatomic barrier breakdown, iron overload, and hyperglycemia/acidosis. Similarly to what occurs with Aspergillus, the host stimulates an innate immune response against the challenging sporangiospores and invading hyphae of Zygomycetes. This article discusses the host defense to different Zygomycetes, its augmentation, and its subsequent impact on the outcome of mucormycosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=84855874847&partnerID=8YFLogxK
U2 - 10.1093/cid/cir869
DO - 10.1093/cid/cir869
M3 - Article
C2 - 22247447
AN - SCOPUS:84855874847
VL - 54
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - SUPPL. 1
ER -