Host defense molecule polymorphisms influence the risk for immune- mediated complications in chronic granulomatous disease

Charles B. Foster, Thomas Lehrnbecher, Femke Mol, Seth M. Steinberg, David J. Venzon, Thomas J. Walsh, Deborah Noack, Julie Rae, Jerry A. Winkelstein, John T. Curnutte, Stephen J. Chanock

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic granulomatous disease (CGD) is an inherited disorder of phagocyte function in which defective superoxide production results in deficient microbicidal activity. CGD patients suffer from recurrent, life- threatening infections, and nearly half develop chronic gastrointestinal (GI) complications (colitis, gastric outlet obstruction, or perirectal abscess) and/or autoimmune/rheumatologic disorders (AIDs). To identify genetic modifiers of disease severity, we studied a cohort of 129 CGD patients, in whom seven candidate genes (myeloperoxidase [MPO], mannose binding lectin [MBL], Fcγ receptors IIa, IIIa, IIIb, TNF-α, and IL-1 receptor antagonist), each containing a physiologically relevant polymorphism predicted to influence the host inflammatory response, were selected for analysis. Genotypes of MPO (P = 0.003) and FcγRIIIb (P = 0.007) were strongly associated with an increased risk for GI complications, while an FcγRIIa (P = 0.05) genotype was suggestive for an association. Patients with all three associated genotypes had the highest risk for GI complications (P < 0.0001). The risk of AIDs was strongly associated with variant alleles of MBL (P = 0.01) and weakly associated with an FcγRIIa genotype (P = 0.04). Patients with variant forms of both MBL and FcγRIIa had the highest risk of developing an AID (P = 0.003).

Original languageEnglish (US)
Pages (from-to)2146-2155
Number of pages10
JournalJournal of Clinical Investigation
Volume102
Issue number12
DOIs
StatePublished - Dec 15 1998

Keywords

  • Fc receptor
  • Gastric outlet obstruction
  • Mannose binding lectin
  • Myeloperoxidase
  • Rheumatological disorders

ASJC Scopus subject areas

  • Medicine(all)

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