Host cell fate on Cryptosporidium parvum egress from MDCK cells

David A. Elliott, Douglas P. Clark

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptosporidium parvum is an intracellular protozoan parasite that causes a severe diarrheal illness of unclear etiology. Also unclear is the fate of the host cell upon parasite egress. We show in an MDCK cell model that the host cell is killed upon parasite egress; this death is necrotic, rather than apoptotic, in nature.

Original languageEnglish (US)
Pages (from-to)5422-5426
Number of pages5
JournalInfection and immunity
Volume71
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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