Hospitalized cardiovascular events in patients with diabetic macular edema

Bao Anh Nguyen-Khoa; Earl L. Goehring; Winifred Werther; Anne E. Fung; Diana V. Do; Rajendra S. Apte; Judith K. Jones

doi:10.1186/1471-2415-12-11

Hospitalized cardiovascular events in patients with diabetic macular edema

Bao Anh Nguyen-Khoa, Earl L. Goehring, Winifred Werther, Anne E. Fung, Diana V. Do, Rajendra S. Apte, Judith K. Jones

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20 Scopus citations

Abstract

Background: Microvascular and macrovascular complications in diabetes stem from chronic hyperglycemia and are thought to have overlapping pathophysiology. The aim of this study was to investigate the incidence rate of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in patients with diabetic macular edema (DME) compared with diabetic patients without retinal diseases. Methods: This was a retrospective cohort study of a commercially insured population in an administrative claims database. DME subjects (n = 3519) and diabetes controls without retinal disease (n = 10557) were matched by age and gender. Healthcare claims were analyzed for the study period from 1 January 2002 to 31 December 2005. Incidence and adjusted rate ratios of hospitalized MI and CVA events were then calculated.Results: The adjusted rate ratio for MI was 2.50 (95% CI: 1.83-3.41, p<0.001) for DME versus diabetes controls. Predictors of MI events were heart disease, history of acute MI, and prior use of antiplatelet or anticoagulant drugs. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.83, p<0.001) for DME versus diabetes controls. Predictors of CVA events were cardiac arrhythmia, Charlson comorbidity scores, history of CVA, hyperlipidemia, and other cerebrovascular diseases. Conclusion: Event rates of MI or CVA were higher in patients with DME than in diabetes controls. This study is one of few with sufficient sample size to accurately estimate the relationship between DME and cardiovascular outcomes.

Original language	English (US)
Article number	11
Journal	BMC Ophthalmology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1471-2415-12-11
State	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1186/1471-2415-12-11

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@article{3a10fe3821944ca3a178f389182884ca,

title = "Hospitalized cardiovascular events in patients with diabetic macular edema",

abstract = "Background: Microvascular and macrovascular complications in diabetes stem from chronic hyperglycemia and are thought to have overlapping pathophysiology. The aim of this study was to investigate the incidence rate of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in patients with diabetic macular edema (DME) compared with diabetic patients without retinal diseases. Methods: This was a retrospective cohort study of a commercially insured population in an administrative claims database. DME subjects (n = 3519) and diabetes controls without retinal disease (n = 10557) were matched by age and gender. Healthcare claims were analyzed for the study period from 1 January 2002 to 31 December 2005. Incidence and adjusted rate ratios of hospitalized MI and CVA events were then calculated.Results: The adjusted rate ratio for MI was 2.50 (95% CI: 1.83-3.41, p<0.001) for DME versus diabetes controls. Predictors of MI events were heart disease, history of acute MI, and prior use of antiplatelet or anticoagulant drugs. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.83, p<0.001) for DME versus diabetes controls. Predictors of CVA events were cardiac arrhythmia, Charlson comorbidity scores, history of CVA, hyperlipidemia, and other cerebrovascular diseases. Conclusion: Event rates of MI or CVA were higher in patients with DME than in diabetes controls. This study is one of few with sufficient sample size to accurately estimate the relationship between DME and cardiovascular outcomes.",

author = "Nguyen-Khoa, {Bao Anh} and Goehring, {Earl L.} and Winifred Werther and Fung, {Anne E.} and Do, {Diana V.} and Apte, {Rajendra S.} and Jones, {Judith K.}",

note = "Funding Information: Genentech Inc. provided financial support to The Degge Group, Ltd. for this study. BN, ELG, and JKJ are employees of The Degge Group, Ltd. No additional funding was received. Neither Genentech nor any representative of the sponsor took part in the collection, management, or analysis of the data. At the time of research, Dr. Werther was an employee of Genentech Inc., her role is described in the authors' contribution section. The decision to publish was made jointly by Genentech and Degge prior to the conduct of this research. The preparation of this manuscript was included in the funding prior to the conduct of research. At the time of research, Dr. Winifred Werther was a senior epidemiologist at the study sponsor, Genentech. Dr Rajendra Apte and Dr Anne Fung have served as consultants and speakers for Genentech. Dr Diana Do and Dr Anne Fung have received clinical research funding from Genentech. Dr. Rajendra Apte has also consulted for Eyetech and Allergan, and has equity ownership in Opthotech. Dr Judith Jones is President of The Degge Group, and Dr Bao-Anh Nguyen-Khoa and Mr Earl Goehring are employees of The Degge Group. The Degge Group had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses.",

year = "2012",

doi = "10.1186/1471-2415-12-11",

language = "English (US)",

volume = "12",

journal = "BMC Ophthalmology",

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number = "1",

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TY - JOUR

T1 - Hospitalized cardiovascular events in patients with diabetic macular edema

AU - Nguyen-Khoa, Bao Anh

AU - Goehring, Earl L.

AU - Werther, Winifred

AU - Fung, Anne E.

AU - Do, Diana V.

AU - Apte, Rajendra S.

AU - Jones, Judith K.

N1 - Funding Information: Genentech Inc. provided financial support to The Degge Group, Ltd. for this study. BN, ELG, and JKJ are employees of The Degge Group, Ltd. No additional funding was received. Neither Genentech nor any representative of the sponsor took part in the collection, management, or analysis of the data. At the time of research, Dr. Werther was an employee of Genentech Inc., her role is described in the authors' contribution section. The decision to publish was made jointly by Genentech and Degge prior to the conduct of this research. The preparation of this manuscript was included in the funding prior to the conduct of research. At the time of research, Dr. Winifred Werther was a senior epidemiologist at the study sponsor, Genentech. Dr Rajendra Apte and Dr Anne Fung have served as consultants and speakers for Genentech. Dr Diana Do and Dr Anne Fung have received clinical research funding from Genentech. Dr. Rajendra Apte has also consulted for Eyetech and Allergan, and has equity ownership in Opthotech. Dr Judith Jones is President of The Degge Group, and Dr Bao-Anh Nguyen-Khoa and Mr Earl Goehring are employees of The Degge Group. The Degge Group had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses.

PY - 2012

Y1 - 2012

N2 - Background: Microvascular and macrovascular complications in diabetes stem from chronic hyperglycemia and are thought to have overlapping pathophysiology. The aim of this study was to investigate the incidence rate of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in patients with diabetic macular edema (DME) compared with diabetic patients without retinal diseases. Methods: This was a retrospective cohort study of a commercially insured population in an administrative claims database. DME subjects (n = 3519) and diabetes controls without retinal disease (n = 10557) were matched by age and gender. Healthcare claims were analyzed for the study period from 1 January 2002 to 31 December 2005. Incidence and adjusted rate ratios of hospitalized MI and CVA events were then calculated.Results: The adjusted rate ratio for MI was 2.50 (95% CI: 1.83-3.41, p<0.001) for DME versus diabetes controls. Predictors of MI events were heart disease, history of acute MI, and prior use of antiplatelet or anticoagulant drugs. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.83, p<0.001) for DME versus diabetes controls. Predictors of CVA events were cardiac arrhythmia, Charlson comorbidity scores, history of CVA, hyperlipidemia, and other cerebrovascular diseases. Conclusion: Event rates of MI or CVA were higher in patients with DME than in diabetes controls. This study is one of few with sufficient sample size to accurately estimate the relationship between DME and cardiovascular outcomes.

AB - Background: Microvascular and macrovascular complications in diabetes stem from chronic hyperglycemia and are thought to have overlapping pathophysiology. The aim of this study was to investigate the incidence rate of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in patients with diabetic macular edema (DME) compared with diabetic patients without retinal diseases. Methods: This was a retrospective cohort study of a commercially insured population in an administrative claims database. DME subjects (n = 3519) and diabetes controls without retinal disease (n = 10557) were matched by age and gender. Healthcare claims were analyzed for the study period from 1 January 2002 to 31 December 2005. Incidence and adjusted rate ratios of hospitalized MI and CVA events were then calculated.Results: The adjusted rate ratio for MI was 2.50 (95% CI: 1.83-3.41, p<0.001) for DME versus diabetes controls. Predictors of MI events were heart disease, history of acute MI, and prior use of antiplatelet or anticoagulant drugs. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.83, p<0.001) for DME versus diabetes controls. Predictors of CVA events were cardiac arrhythmia, Charlson comorbidity scores, history of CVA, hyperlipidemia, and other cerebrovascular diseases. Conclusion: Event rates of MI or CVA were higher in patients with DME than in diabetes controls. This study is one of few with sufficient sample size to accurately estimate the relationship between DME and cardiovascular outcomes.

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Hospitalized cardiovascular events in patients with diabetic macular edema

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