Hospitalization and surgical rates in patients with Crohn's disease treated with infliximab: A matched analysis

John Paul Leombruno, Geoffrey C. Nguyen, Paul Grootendorst, David Juurlink, Tom Einarson

Research output: Contribution to journalArticle

Abstract

Purpose: The majority of subjects with Crohn's Disease (CD) will be hospitalized and will receive surgery for their disease. These interventions account for most of the direct costs of the disease. We sought to explore the association between infliximab use and CD-related surgery and hospitalizations. Methods: We obtained patient-level health claims between 1996 and 2007 from the Régie de l'Assurance Maladie du Québec (RAMQ), a Canadian provincial health care insurer. Subjects who were i) enrolled in the RAMQ for at least 2years, ii) received prescription drug benefits for each year of enrolment and iii) were identified as having CD using a validated algorithm were eligible for the study. For each subject treated with infliximab, up to two closely matched comparison subjects were selected using propensity score methods. We compared time to first CD-related intra-abdominal surgery or hospitalization in infliximab users and non-users. Results: We matched 338 infliximab users (mean age 34, 45% male) to at least one comparison subject using propensity score matching. Subjects who received infliximab had a significantly lower risk of experiencing a CD-related intra-abdominal surgery (hazard ratio [HR]=0.64; 95% confidence interval [CI] 0.51-0.81) or hospitalization (HR=0.73; 95% CI 0.63-0.85). Infliximab users also experienced lower rates of hospitalized days (Rate Ratio=0.69; 95% CI 0.49-0.97). Conclusions: Our results support the real world effectiveness of infliximab therapy in reducing CD-related surgeries and hospitalizations.

Original languageEnglish (US)
Pages (from-to)838-848
Number of pages11
JournalPharmacoepidemiology and Drug Safety
Volume20
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • Crohn's disease
  • Hospitalization
  • Infliximab
  • Propensity score
  • Surgery

ASJC Scopus subject areas

  • Epidemiology
  • Pharmacology (medical)

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