Hospital outbreak of middle east respiratory syndrome coronavirus

Abdullah Assiri, Allison McGeer, Trish M. Perl, Connie S. Price, Abdullah A. Al Rabeeah, Derek A T Cummings, Zaki N. Alabdullatif, Maher Assad, Abdulmohsen Almulhim, Hatem Makhdoom, Hossam Madani, Rafat Alhakeem, Jaffar A. Al-Tawfiq, Matthew Cotten, Simon J. Watson, Paul Kellam, Alimuddin I. Zumla, Ziad A. Memish

Research output: Contribution to journalArticle

Abstract

BACKGROUND: In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERSCoV). We describe a cluster of health care-acquired MERS-CoV infections. METHODS: Medical records were reviewed for clinical and demographic information and determination of potential contacts and exposures. Case patients and contacts were interviewed. The incubation period and serial interval (the time between the successive onset of symptoms in a chain of transmission) were estimated. Viral RNA was sequenced. RESULTS: Between April 1 and May 23, 2013, a total of 23 cases of MERS-CoV infection were reported in the eastern province of Saudi Arabia. Symptoms included fever in 20 patients (87%), cough in 20 (87%), shortness of breath in 11 (48%), and gastrointestinal symptoms in 8 (35%); 20 patients (87%) presented with abnormal chest radiographs. As of June 12, a total of 15 patients (65%) had died, 6 (26%) had recovered, and 2 (9%) remained hospitalized. The median incubation period was 5.2 days (95% confidence interval [CI], 1.9 to 14.7), and the serial interval was 7.6 days (95% CI, 2.5 to 23.1). A total of 21 of the 23 cases were acquired by person-to-person transmission in hemodialysis units, intensive care units, or in-patient units in three different health care facilities. Sequencing data from four isolates revealed a single monophyletic clade. Among 217 household contacts and more than 200 health care worker contacts whom we identified, MERS-CoV infection developed in 5 family members (3 with laboratory-confirmed cases) and in 2 health care workers (both with laboratory-confirmed cases). CONCLUSIONS: Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalNew England Journal of Medicine
Volume369
Issue number5
DOIs
StatePublished - 2013

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Disease Outbreaks
Delivery of Health Care
Infection
Confidence Intervals
Saudi Arabia
Health Facilities
Viral RNA
Infection Control
Cough
Dyspnea
Medical Records
Intensive Care Units
Renal Dialysis
Pneumonia
Fever
Thorax
Public Health
Demography
Middle East Respiratory Syndrome Coronavirus
Morbidity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Assiri, A., McGeer, A., Perl, T. M., Price, C. S., Al Rabeeah, A. A., Cummings, D. A. T., ... Memish, Z. A. (2013). Hospital outbreak of middle east respiratory syndrome coronavirus. New England Journal of Medicine, 369(5), 407-416. https://doi.org/10.1056/NEJMoa1306742

Hospital outbreak of middle east respiratory syndrome coronavirus. / Assiri, Abdullah; McGeer, Allison; Perl, Trish M.; Price, Connie S.; Al Rabeeah, Abdullah A.; Cummings, Derek A T; Alabdullatif, Zaki N.; Assad, Maher; Almulhim, Abdulmohsen; Makhdoom, Hatem; Madani, Hossam; Alhakeem, Rafat; Al-Tawfiq, Jaffar A.; Cotten, Matthew; Watson, Simon J.; Kellam, Paul; Zumla, Alimuddin I.; Memish, Ziad A.

In: New England Journal of Medicine, Vol. 369, No. 5, 2013, p. 407-416.

Research output: Contribution to journalArticle

Assiri, A, McGeer, A, Perl, TM, Price, CS, Al Rabeeah, AA, Cummings, DAT, Alabdullatif, ZN, Assad, M, Almulhim, A, Makhdoom, H, Madani, H, Alhakeem, R, Al-Tawfiq, JA, Cotten, M, Watson, SJ, Kellam, P, Zumla, AI & Memish, ZA 2013, 'Hospital outbreak of middle east respiratory syndrome coronavirus', New England Journal of Medicine, vol. 369, no. 5, pp. 407-416. https://doi.org/10.1056/NEJMoa1306742
Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DAT et al. Hospital outbreak of middle east respiratory syndrome coronavirus. New England Journal of Medicine. 2013;369(5):407-416. https://doi.org/10.1056/NEJMoa1306742
Assiri, Abdullah ; McGeer, Allison ; Perl, Trish M. ; Price, Connie S. ; Al Rabeeah, Abdullah A. ; Cummings, Derek A T ; Alabdullatif, Zaki N. ; Assad, Maher ; Almulhim, Abdulmohsen ; Makhdoom, Hatem ; Madani, Hossam ; Alhakeem, Rafat ; Al-Tawfiq, Jaffar A. ; Cotten, Matthew ; Watson, Simon J. ; Kellam, Paul ; Zumla, Alimuddin I. ; Memish, Ziad A. / Hospital outbreak of middle east respiratory syndrome coronavirus. In: New England Journal of Medicine. 2013 ; Vol. 369, No. 5. pp. 407-416.
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AU - Alabdullatif, Zaki N.

AU - Assad, Maher

AU - Almulhim, Abdulmohsen

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AU - Madani, Hossam

AU - Alhakeem, Rafat

AU - Al-Tawfiq, Jaffar A.

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