Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005

M. Jahangir Hossain; Emily S. Gurley; Susan Montgomery; Lyle Petersen; James Sejvar; Marc Fischer; Amanda Panella; Ann M. Powers; Nazmun Nahar; A. K.M.Rafique Uddin; M. Ekhlasur Rahman; A. R.M.Saifuddin Ekram; Stephen P. Luby; Robert F. Breiman

doi:10.4269/ajtmh.2010.09-0125

Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005

M. Jahangir Hossain, Emily S. Gurley, Susan Montgomery, Lyle Petersen, James Sejvar, Marc Fischer, Amanda Panella, Ann M. Powers, Nazmun Nahar, A. K.M.Rafique Uddin, M. Ekhlasur Rahman, A. R.M.Saifuddin Ekram, Stephen P. Luby, Robert F. Breiman

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27 Scopus citations

Abstract

We investigated the epidemiology and etiology of encephalitis at four tertiary hospitals in Bangladesh during 2003-2005. Patients who met a clinical case definition for acute encephalitis and had cerebrospinal fluid (CSF) pleocytosis were eligible for enrollment; a standardized sampling pattern was used to enroll eligible patients. Recent Japanese encephalitis virus (JEV) infection was defined by presence of IgM antibodies against JEV in CSF or serum.Twenty (4%) of 492 cases had laboratory evidence of recent JEV infection; two died. All JE cases occurred during May-December, and cases were identified among all age groups. All cases resided in rural areas. Fifteen patients were re-assessed 4-6 weeks after hospitalization; 5 (33%) patients had physical disabilities and 7 (47%) reported cognitive difficulties. Infection with JEV is clearly an etiology of encephalitis in Bangladesh. Population-based studies to quantify burden of disease could assess options for targeted immunization programs.

Original language	English (US)
Pages (from-to)	344-349
Number of pages	6
Journal	American Journal of Tropical Medicine and Hygiene
Volume	82
Issue number	2
DOIs	https://doi.org/10.4269/ajtmh.2010.09-0125
State	Published - Feb 2010
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Virology
Parasitology

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Hossain, M. J., Gurley, E. S., Montgomery, S., Petersen, L., Sejvar, J., Fischer, M., Panella, A., Powers, A. M., Nahar, N., Uddin, A. K. M. R., Rahman, M. E., Ekram, A. R. M. S., Luby, S. P., & Breiman, R. F. (2010). Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005. American Journal of Tropical Medicine and Hygiene, 82(2), 344-349. https://doi.org/10.4269/ajtmh.2010.09-0125

Hossain, MJ, Gurley, ES, Montgomery, S, Petersen, L, Sejvar, J, Fischer, M, Panella, A, Powers, AM, Nahar, N, Uddin, AKMR, Rahman, ME, Ekram, ARMS, Luby, SP & Breiman, RF 2010, 'Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005', American Journal of Tropical Medicine and Hygiene, vol. 82, no. 2, pp. 344-349. https://doi.org/10.4269/ajtmh.2010.09-0125

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abstract = "We investigated the epidemiology and etiology of encephalitis at four tertiary hospitals in Bangladesh during 2003-2005. Patients who met a clinical case definition for acute encephalitis and had cerebrospinal fluid (CSF) pleocytosis were eligible for enrollment; a standardized sampling pattern was used to enroll eligible patients. Recent Japanese encephalitis virus (JEV) infection was defined by presence of IgM antibodies against JEV in CSF or serum.Twenty (4%) of 492 cases had laboratory evidence of recent JEV infection; two died. All JE cases occurred during May-December, and cases were identified among all age groups. All cases resided in rural areas. Fifteen patients were re-assessed 4-6 weeks after hospitalization; 5 (33%) patients had physical disabilities and 7 (47%) reported cognitive difficulties. Infection with JEV is clearly an etiology of encephalitis in Bangladesh. Population-based studies to quantify burden of disease could assess options for targeted immunization programs.",

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AU - Powers, Ann M.

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AU - Rahman, M. Ekhlasur

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Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005

Abstract

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