Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005

M. Jahangir Hossain, Emily S. Gurley, Susan Montgomery, Lyle Petersen, James Sejvar, Marc Fischer, Amanda Panella, Ann M. Powers, Nazmun Nahar, A. K.M.Rafique Uddin, M. Ekhlasur Rahman, A. R.M.Saifuddin Ekram, Stephen P. Luby, Robert F. Breiman

Research output: Contribution to journalArticle

Abstract

We investigated the epidemiology and etiology of encephalitis at four tertiary hospitals in Bangladesh during 2003-2005. Patients who met a clinical case definition for acute encephalitis and had cerebrospinal fluid (CSF) pleocytosis were eligible for enrollment; a standardized sampling pattern was used to enroll eligible patients. Recent Japanese encephalitis virus (JEV) infection was defined by presence of IgM antibodies against JEV in CSF or serum.Twenty (4%) of 492 cases had laboratory evidence of recent JEV infection; two died. All JE cases occurred during May-December, and cases were identified among all age groups. All cases resided in rural areas. Fifteen patients were re-assessed 4-6 weeks after hospitalization; 5 (33%) patients had physical disabilities and 7 (47%) reported cognitive difficulties. Infection with JEV is clearly an etiology of encephalitis in Bangladesh. Population-based studies to quantify burden of disease could assess options for targeted immunization programs.

Original languageEnglish (US)
Pages (from-to)344-349
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume82
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Hossain, M. J., Gurley, E. S., Montgomery, S., Petersen, L., Sejvar, J., Fischer, M., Panella, A., Powers, A. M., Nahar, N., Uddin, A. K. M. R., Rahman, M. E., Ekram, A. R. M. S., Luby, S. P., & Breiman, R. F. (2010). Hospital-based surveillance for Japanese encephalitis at four sites in Bangladesh, 2003-2005. American Journal of Tropical Medicine and Hygiene, 82(2), 344-349. https://doi.org/10.4269/ajtmh.2010.09-0125