Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: A substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial

Mark Kelemen, Dhananjay Vaidya, David D. Waters, Barbara V. Howard, Frederick Cobb, Naji Younes, Mark Tripputti, Pamela Ouyang

Research output: Contribution to journalArticlepeer-review

Abstract

We measured flow-mediated dilation (FMD) by high-resolution brachial ultrasound in 61 women who participated in the Women's Angiographic Vitamin and Estrogen (WAVE) trial, a randomized controlled trial. There were no significant differences in the baseline demographics of women receiving hormone therapy (0.625 mg/day of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate for women who had not had a hysterectomy) or placebo; or vitamins (400 IU of Vitamin E and 500 mg of Vitamin C twice daily) or placebo. Baseline FMD was impaired in all subjects (3.3 ± 7.6%). Neither hormone therapy (4.1 ± 5.2% at baseline, 4.2 ± 5.0% at 3 months, and 4.1 ± 6.5% at 34 months) nor antioxidant vitamins (3.0 ± 8.3% at baseline; 3.5 ± 4.6% at 3 months; 3.1 ± 7.6% at 34 months) improved FMD (all p-values = NS). Endothelium-independent vasodilation, induced by nitroglycerin (NTG) was similar at baseline and was not affected by either therapy. In univariate and multivariate analysis, neither hormone therapy nor antioxidant vitamins were associated with FMD. Women with established coronary artery disease have impaired flow-mediated vasodilation of the brachial artery that does not improve after 3 months or up to 34 months of treatment with postmenopausal hormone therapy or antioxidant vitamins.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalAtherosclerosis
Volume179
Issue number1
DOIs
StatePublished - Mar 2005

Keywords

  • Antioxidant therapy
  • Brachial ultrasound
  • Coronary artery disease
  • Endothelial function
  • Hormone therapy
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: A substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial'. Together they form a unique fingerprint.

Cite this