Purpose: Estrogens have vasomotor effects in vitro and in vivo. We evaluated the influence of postmenopausal hormone replacement therapy on myocardial perfusion and vasoreactivity with non-invasive positron emission tomography (PET). Methods: Ten women with risk factors for coronary artery disease and seven women with angiographically-confirmed coronary artery disease underwent PET of the heart at rest and during adenosine-induced stress. The flow reserve (ratio of blood flow under stress to blood flow at rest) and other hemodynamic parameters were calculated from blood flow measurements. Hormone replacement with conjugated estrogens and medrogestone was initiated and PET repeated after about 6 weeks. Results: Hemodynamic values were unchanged under hormone replacement therapy both in women with risk factors and in those with confirmed coronary artery disease (myocardial blood flow, 90±26 vs. 91±25 and 92±30 vs. 86±24 mL/100g/min; blood flow under stress, 288±64 vs. 273±52 and 269±60 vs. 232±47 mL/100g/min; myocardial flow reserve, 3.5±1.4 vs. 3.3±1.4 and 3.1 ±1.1 vs. 2.9±1.1, respectively). Conclusion: Hormone replacement therapy did not influence myocardial perfusion in postmenopausal women with risk factors for or with established coronary artery disease.
|Translated title of the contribution||Hormone replacement therapy and myocardial perfusion in postmenopausal women: Evaluation with positron-emission-tomography|
|Number of pages||7|
|Journal||Geburtshilfe und Frauenheilkunde|
|State||Published - 2002|
- Hormone replacement
ASJC Scopus subject areas
- Obstetrics and Gynecology