Hormone receptors in breast cancer

K. P.M. Suijkerbuijk; E. van der Wall; P. J. van Diest

doi:10.1007/978-3-319-41761-5_4

Hormone receptors in breast cancer

K. P.M. Suijkerbuijk, E. van der Wall, P. J. van Diest

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Steroid hormone receptors are critical for the growth and development of breast tissue as well as of breast cancer. The importance of the role estrogens in breast cancer has been delineated for more than 100 years. The analysis of its expression has been used not only to classify breast cancers but also for treating patients. The expression of ER and PR in tumors is associated with better prognosis and sensitivity to endocrine therapy. In this chapter we discuss the role of these receptors in addition to androgen receptor (AR) in breast cancer. A brief overview of the structure and function of these receptors and methods to detect their presence in breast cancer is presented. This includes criteria for scoring positivity and national and international guidelines associated with the scoring. Lastly, data regarding the use of expression of AR as therapeutic target, particularly in triple negative cancers, is presented.

Original language	English (US)
Title of host publication	Molecular Pathology of Breast Cancer
Publisher	Springer International Publishing
Pages	45-58
Number of pages	14
ISBN (Electronic)	9783319417615
ISBN (Print)	9783319417592
DOIs	https://doi.org/10.1007/978-3-319-41761-5_4
State	Published - Jan 1 2016

Keywords

ASCO-CAP
Endocrine therapy
Estrogen
Progesterone and androgen receptors
Scoring

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-319-41761-5_4

Cite this

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AU - van Diest, P. J.

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AB - Steroid hormone receptors are critical for the growth and development of breast tissue as well as of breast cancer. The importance of the role estrogens in breast cancer has been delineated for more than 100 years. The analysis of its expression has been used not only to classify breast cancers but also for treating patients. The expression of ER and PR in tumors is associated with better prognosis and sensitivity to endocrine therapy. In this chapter we discuss the role of these receptors in addition to androgen receptor (AR) in breast cancer. A brief overview of the structure and function of these receptors and methods to detect their presence in breast cancer is presented. This includes criteria for scoring positivity and national and international guidelines associated with the scoring. Lastly, data regarding the use of expression of AR as therapeutic target, particularly in triple negative cancers, is presented.

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KW - Progesterone and androgen receptors

KW - Scoring

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Hormone receptors in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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