Hormone-mediated watery diarrhea in a family with multiple endocrine neoplasms

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A father and son each presented with severe watery diarrhea. The son was found to have a pancreatic islet-cell tumor associated with the pancreatic cholera syndrome, as well as a parathyroid adenoma. The father was found to have multiple islet-cell adenomas and the Zollinger-Ellison syndrome. Pancreatic tumor tissue from each patient contained detectable gastrin and vasoactive intestinal peptide; however, a much higher gastrin concentration was found in the tumor tissue from the father and a much higher vasoactive intestinal peptide content in the tumor tissue from the son. Thus, watery diarrhea may be mediated by different hormones in families having multiple endocrine neoplasia; the precise cause of the diarrheal syndrome should be defined to ensure the proper therapy.

Original languageEnglish (US)
Pages (from-to)932-934
Number of pages3
JournalAnnals of internal medicine
Issue number6
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Internal Medicine


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