TY - JOUR
T1 - Hormone levels before and after tubal sterilization
AU - Gentile, Gwen P.
AU - Helbig, Donald W.
AU - Zacur, Howard
AU - Park, Taesung
AU - Lee, Young Jack
AU - Westhoff, Carolyn L.
N1 - Funding Information:
The authors thank Barbara Driscoll, R.N., for her assistance in data collection, drawing blood samples and maintaining patient follow-up. This project was funded, in part, with federal funds from the National Institute of Child Health and Human Development, National Institutes of Health, under Contract Number NO1HD052908. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government.
PY - 2006/5
Y1 - 2006/5
N2 - Objective: The aim of this study was to determine whether women experience significant luteal phase hormonal changes following interval tubal sterilization. Design: This is a partly randomized, prospective clinical study. Setting: This study involved healthy volunteers in an academic research environment. Patients: This study involved 118 fertile women seeking tubal sterilization and 57 fertile controls with at least three normal cyclic menstrual periods before entry into the study. Interventions: The patients were randomized to bipolar cautery or Hulka clip as sterilization methods. Barrier contraception or abstinence was used by controls. Main Outcome Measures: The main outcome measures are serum estradiol and progesterone levels and urinary estradiol and pregnanediol levels obtained during the luteal phase before, 1 year and 2 years after sterilization. Results: The women randomized to the bipolar cautery group had higher midluteal progesterone levels measured between Days 5 and 11 postovulation (15.5 ng/mL before sterilization, 14.5 ng/mL at 1 year and 14.5 ng/mL at 2 years) than did the other two groups. The clip group had progesterone levels of 14.1, 12.0 and 12.5 ng/mL at baseline, 1 year and 2 years, respectively, and the control group had levels of 12.0, 11.9 and 11.3 ng/mL for the same periods. Serum estradiol and progesterone and urinary pregnanediol and estradiol were not significantly changed over the 2-year period, nor were there significant differences between the two groups. Conclusions: There were no significant hormonal changes in sterilized women over a period of 2 years when compared with their baseline levels or when compared with unsterilized age-matched controls.
AB - Objective: The aim of this study was to determine whether women experience significant luteal phase hormonal changes following interval tubal sterilization. Design: This is a partly randomized, prospective clinical study. Setting: This study involved healthy volunteers in an academic research environment. Patients: This study involved 118 fertile women seeking tubal sterilization and 57 fertile controls with at least three normal cyclic menstrual periods before entry into the study. Interventions: The patients were randomized to bipolar cautery or Hulka clip as sterilization methods. Barrier contraception or abstinence was used by controls. Main Outcome Measures: The main outcome measures are serum estradiol and progesterone levels and urinary estradiol and pregnanediol levels obtained during the luteal phase before, 1 year and 2 years after sterilization. Results: The women randomized to the bipolar cautery group had higher midluteal progesterone levels measured between Days 5 and 11 postovulation (15.5 ng/mL before sterilization, 14.5 ng/mL at 1 year and 14.5 ng/mL at 2 years) than did the other two groups. The clip group had progesterone levels of 14.1, 12.0 and 12.5 ng/mL at baseline, 1 year and 2 years, respectively, and the control group had levels of 12.0, 11.9 and 11.3 ng/mL for the same periods. Serum estradiol and progesterone and urinary pregnanediol and estradiol were not significantly changed over the 2-year period, nor were there significant differences between the two groups. Conclusions: There were no significant hormonal changes in sterilized women over a period of 2 years when compared with their baseline levels or when compared with unsterilized age-matched controls.
KW - Bipolar tubal cauterization
KW - Estradiol level
KW - Hulka clip sterilization
KW - Laparoscopic tubal sterilization
KW - Luteal phase hormonal levels
KW - Posttubal sterilization syndrome
KW - Progesterone level
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U2 - 10.1016/j.contraception.2005.12.002
DO - 10.1016/j.contraception.2005.12.002
M3 - Article
C2 - 16627035
AN - SCOPUS:33646073721
SN - 0010-7824
VL - 73
SP - 507
EP - 511
JO - Contraception
JF - Contraception
IS - 5
ER -