TY - JOUR
T1 - Hormone and hormonal agents in the treatment of aggression
AU - Blumer, Dietrich
AU - Migeon, Claude
PY - 1975/2
Y1 - 1975/2
N2 - Evidence for the role of androgens in the male aggressive and sexual behavior is reviewed. Medroxyprogesterone acetate (MPA; Provera, Upjohn) has a marked antiandrogen property; it is effective in lowering the testosterone level and controlling certain otherwise intractable sex deviations. The finding in 6 patients treated for sex deviation are summarized. The effects of MPA in the treatment of 11 temporal lobe epileptics and 5 other patients with severe angry-aggressive behavior disorder are reported. Most temporal lobe epileptics responded well to MPA. Weight gain and earlier sleep were consistent side effects. The values of plasma testosterone, serum luteinizing hormone, and urinary 17-ketosteroids were decreased by the treatment. Pour patients were XYY individuals with lack of control over their sexual-aggressive or angry-aggressive impulses.
AB - Evidence for the role of androgens in the male aggressive and sexual behavior is reviewed. Medroxyprogesterone acetate (MPA; Provera, Upjohn) has a marked antiandrogen property; it is effective in lowering the testosterone level and controlling certain otherwise intractable sex deviations. The finding in 6 patients treated for sex deviation are summarized. The effects of MPA in the treatment of 11 temporal lobe epileptics and 5 other patients with severe angry-aggressive behavior disorder are reported. Most temporal lobe epileptics responded well to MPA. Weight gain and earlier sleep were consistent side effects. The values of plasma testosterone, serum luteinizing hormone, and urinary 17-ketosteroids were decreased by the treatment. Pour patients were XYY individuals with lack of control over their sexual-aggressive or angry-aggressive impulses.
UR - http://www.scopus.com/inward/record.url?scp=0016611339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016611339&partnerID=8YFLogxK
U2 - 10.1097/00005053-197502000-00007
DO - 10.1097/00005053-197502000-00007
M3 - Article
C2 - 123269
AN - SCOPUS:0016611339
VL - 160
SP - 127
EP - 137
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
SN - 0022-3018
IS - 2
ER -