Hormonal therapy in breast cancer: A model disease for the personalization of cancer care

Shannon Puhalla; Saveri Bhattacharya; Nancy E. Davidson

doi:10.1016/j.molonc.2012.02.003

Hormonal therapy in breast cancer: A model disease for the personalization of cancer care

Shannon Puhalla, Saveri Bhattacharya, Nancy E. Davidson

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.

Original language	English (US)
Pages (from-to)	222-236
Number of pages	15
Journal	Molecular oncology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.molonc.2012.02.003
State	Published - Apr 2012
Externally published	Yes

Keywords

Aromatase inhibitors
Breast cancer
Endocrine therapy
Estrogen receptor
Prognostic assays
Tamoxifen

ASJC Scopus subject areas

Genetics
Molecular Medicine
Oncology
Cancer Research

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10.1016/j.molonc.2012.02.003

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abstract = "The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.",

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AU - Davidson, Nancy E.

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N2 - The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.

AB - The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.

KW - Aromatase inhibitors

KW - Breast cancer

KW - Endocrine therapy

KW - Estrogen receptor

KW - Prognostic assays

KW - Tamoxifen

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Hormonal therapy in breast cancer: A model disease for the personalization of cancer care

Abstract

Keywords

ASJC Scopus subject areas

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